Treatment of human plasma with brown recluse spider toxin to emu

Details Treatment of human plasma with brown recluse spider toxin to emu Treatment of human plasma with brown recluse spider toxin to emu

1988-10-24

1989-10-31

Rosen, Sam

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

435 13, 436 69, 436536, G01N 3100

Patent

active

048777412

ABSTRACT:
A new method for improving the accuracy of blood tests for the presence of lupus anticoagulants and for blood factor deficiencies is disclosed. Brown recluse spiders are collected, their venon glands removed by microdissection and the active toxin extracted. The toxin is mixed with normal donor plasma in concentrations of about 3.5 .mu.l/ml of toxin to plasma. The treated plasma successfully mimics human plasma having lupus anticoagulants. By using the treated plasma in blood tests and assays as a standardized control to which the results from tests on questioned blood plasma samples may be compared, the equipment and procedures for those tests may be calibrated and test results made more sensitive and reliable.

REFERENCES:
patent: 4341762 (1982-07-01), Haast
patent: 4472303 (1984-09-01), Tabihara et al.
Kurpiewski et al.-Chem. Abst. vol. 96 (1982) p. 47334j.
Purification and Characterization of a Toxin from Brown Recluse Spider Venon Gland Extracts, James L. Babcock et al, Toxicon, vol. 19, No. 5, pp. 667-689, 1981.
Immunotoxicology of Brown Recluse Spider Venon, James L. Babcock et al, Toxicon, vol. 24, No. 8, pp. 783-790, 1986.

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