Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1996-03-14
1998-11-24
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241331, 4241441, 4241541, 4241301, 53038825, A61K 39395, C07K 1628
Patent
active
058403051
ABSTRACT:
The present invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner or receptor as a target for intervention. The present invention relates to the use of exogenous or engrafted sources of cyclophilins, anti-cyclophilin antibodies, cyclophilin decoys, soluble forms of cyclophilin-binding partners and small molecules which are supplied extracellularly, and act presumably by interrupting the binding of cyclophilin A with its cellular binding partner(s) or receptor(s) as a treatment for HIV-infection. The present invention further relates to the use of forms of cyclosporin A that have been derivatized by bulky or charged substituents to inhibit cellular uptake and minimize their immunosuppressive activities, which presumably act to disrupt cyclophilin binding to its cellular receptor, likewise as a treatment for HIV-infection. The present invention further relates to genetic constructs to interfere with production and release of cyclophilin and its cognate cellular binding partner(s), to treat HIV-infection. The present invention further relates to screening assays for the identification of compounds which inhibit the interaction of cyclophilin and its cellular receptor.
REFERENCES:
Burnham Am. J. Hosp. Pharm. 51:210, 1994.
Fahey et al. Clin. Exp. Immunol. 88:1, 1992.
Bukrinsky Michael
Cerami Anthony
Sherry Barbara A.
Ulrich Peter C.
Cunningham Thomas M.
Lubet Martha
Oster Jeffrey B.
The Picower Institute for Medical Research
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