Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1995-01-26
1998-11-03
Lukton, David
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530329, 530327, 514 14, 514 15, 514 16, A61K 3808
Patent
active
058310010
ABSTRACT:
Described herein are oligopeptides useful to inhibit replication of herpesviruses, especially herpes simplex viruses. In a preferred embodiment of the invention, the oligopeptide is a D-arginine nonamer having N- and C-terminal protecting groups, which, at a 5 uM concentration, exhibits greater than 95% inhibition of HSV-1 replication, in a standard assay.
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Barnett Richard W.
Reid Lorne S.
Sumner-Smith Martin
Twist Michael
Allelix Biopharmaceuticals Inc.
Lukton David
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