Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1980-10-02
1982-03-16
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424311, A61K 3122, A61K 31195
Patent
active
043201466
ABSTRACT:
Novel compounds are prepared by reacting ornithine or arginine with alpha ketao analogs of branched chain essential amino acids, namely valine, leucine and isoleucine. The compounds are useful either individually or as a mixture in the treatment of hepatic disorders which are characterized by hyperammonemia and portal systemic encephalopathy. Use of these compounds in treatment of renal failure also appears promising.
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patent: 4100293 (1978-07-01), Walser
Matsuzawa, J. Biochemistry, 75:601-609 (1974).
Chainuvati et al., Acta Hepato-Gastroenterol 24 (1977), 434-439.
Rognstad; Biochimica et Biophysica Acta 496, 249-254 (1977).
Kisfaludy, Mat. Med. Norden 29 (1977), pp. 315-325.
Molimard et al., III, Internationales Ammonich Symposium (1977), pp. 200-206.
Muting et al., Munchener Medizinische Wochenschrift (1977), pp. 1-12.
Robinson Allen J.
The Johns Hopkins University
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