Perfume compositions – Perfume compositions – Ring containing active ingredient
Reexamination Certificate
2008-09-02
2008-09-02
Crouch, Deborah (Department: 1632)
Perfume compositions
Perfume compositions
Ring containing active ingredient
C800S007000, C530S381000
Reexamination Certificate
active
11117705
ABSTRACT:
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5′-untranslated and 3′-untranslated region, which is substituted with a 5-′ and 3′-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described.
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Drohan William N.
Johnson, legal representative Mary Ann H.
Lubon Henryk
Velander William H.
American Red Cross
Cooley Godward Kronish LLP
Crouch Deborah
Virginia Tech Intellectual Properties Inc.
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