Treatment of hemoglobin with nitric oxide

Details Treatment of hemoglobin with nitric oxide Treatment of hemoglobin with nitric oxide

1998-07-02

2000-07-11

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424 9373, A01N 102, B24C 508

Patent

active

060870877

ABSTRACT:
Methods and compositions are provided for treating diluents (including whole blood or at least one blood component) comprising hemoglobin containing erythrocytes (i.e., red blood cells), in order to increase the oxygen delivery capacity of the hemoglobin, wherein nitric oxide is bound to most or all of the hemoglobin present in said erythrocytes as .alpha.-nitrosyl-hemoglobin or its oxygen bound forms.

REFERENCES:
patent: 5834030 (1998-11-01), Bolton
Cassoly, R., "Use of Nitric Oxide As a Probe for Assessing the Formation of Asymmetrical Hemoglobin Hybrids," J. Biol. Chem. 253:3602-3606 (1978).
Doyle, M.P., and Hoekstra, J.W., "Oxidation of Nitrogen Oxides by Bound Dioxygen in Hemoproteins," J. Inorg. Chem. 14:351-358 (Jul. 1981).
Fujii, M., et al., "The Porphyrin-Iron Hybrid Hemoglobins. Absence of the Fe-His bonds in one type of subunits favors a deoxy-like structure with low oxygen affinity," J. Biol. Chem. 268:15386-15393 (Jul. 1993).
Henry, Y., and Banerjee, R., "Electron Paramagnetic Studies of Nitric Oxide Haemoglobin Derivatives: Isolated Subunits and Nitric Oxide Hybrids," J. Mol. Biol. 73:469-482 (Feb. 1973).
Hille, R., et al., "Spectral transitions of nitrosyl hemes during ligand binding to hemoglobin," J. Biol. Chem. 254:12110-12120 (Dec. 1979).
Kosaka, H., et al., "ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats," Am. J. Physiol. 266:C14000-C1405 (May 1994).
Kosaka, H., and Seiyama, A., "Physiological Role of Nitric Oxide as an Enhancer of Oxygen Transfer from Erythrocytes to Tissues," Biochem. Biophys. Res. Commun. 218:749-752 (Jan. 1996).
Kosaka, H., and Seiyama, A., "Elevation of oxygen release by nitroglycerin without an increase in blood flow in the hepatic microcirculation," Nature Medicine 3:456-459 (Apr. 1997).
Nagai, K., et al., "The Effect of Quaternary Structure on the State of the .alpha. and .beta. Subunits within Nitrosyl Haemoglobin. Low temperature photodissociation and the ESR spectra," Biochem. Biophys. Acta 532:17-28 (Jan. 1978).
Moore, E.G., and Gibson, Q.H., "Cooperativity in the dissociation of nitric oxide from hemoglobin," J. Biol. Chem. 251:2788-2794 (May 1976).
Pepke-Zaba, J., et al., "Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension," Lancet 338:1173-1174 (Nov. 1991).
Taketa, F., et al., "Chain Nonequivalence in Binding of Nitric Oxide to Hemoglobin," J. Biol. Chem. 253:5448-2451 (1978).
Traylor, T.G., and Sharma, V.S., "Why NO?," Biochemistry 31:2847-2849 (Mar. 1992).
Tsuneshige, A., and Yonetani, T., "Functional Studies of the Interaction of Hemoglobin (HbA) with NO And O.sub.s. Binding of Nitric Oxide to .alpha.-Subunits of HbA Converts HbA to a Low-Affinity, Allosteric O.sub.2 -Carrier thus NO is a Negative Allosteric Effector of HbA to Facilitate Effective Oyxgen Delivery," Biophys. J. 70:A220 (1996).
Yonetani, T., et al., "Electromagnetic Properties of Hemoproteins. V. Optical and Electron Paramagnetic Resonance Characteristics of Nitric Oxide Derivatives of Metalloporphyrin-Apohemoprotein Complexes," J. Biol. Chem. 247:2447-2455 (Apr. 1972).
Yonetani, T., "Nitrogen Monoxide (NO) in the Blood. Poison Gas or Life Saver? EPR, NMR, and Functional Studies of the Interaction of Hemoglobin (Hb) with NO," Proc. Japanese Medical Soc. Magn. Resom, Kanagawa, Japan (1995).
Yonetani, T., and Tsuneshige, A., "Nitric Oxide (NO) in the Blood: EPR, NMR, and Functional Studies of the Interaction of Hemoglobin (HbA) with NO, show that NO is a Negative Allosteric Effector of HbA to Facilitate Effective Oxygen Delivery," Biophys. J. 70:A220 (1996).
Yonetani, T., "Nitric Oxide in the Blood: Coordination chemistry, magnetic resonance, and biological function," Proc. 35.sup.th ESR Discussion Conference, Yamagata, Japan, p. 15, Abstract No. 106S (1996).
Imai, Allosteric effects in haemoglobin, Cambridge University Press, London (1982).
Chen et al., Biophysical Journal, 74:A80 (1998).
Gibson et al., Proc. Roy. Soc. London B. Biol. Sci. 163:197-205 (1965).
Jia et al., Nature 380:221-226 (1996).
Huang, J. Biol. Chem. 254:22:11467-11474 (1979).
Imai et al., Biochemica et Biophysica Acta 490:164-170 (1977).
Shiga et al., Biochemistry 8:1:378-383 (1969).
Perutz, Nature 228:726-739 (1970).
Rein et al., Febs Letters 24:1:24-26 (1972).
Wayland et al., J Amer. Chem. Soc. 96:19:6037-6040 (1974).
Maxwell et al., Biochemistry 15:2:388-396 (1976).
Nagai et al., Proc. Natl. Acad. Sci. USA 77:4:2033-2037 (1980).
Suzuki et al., Biochem. and Biophy. Res. Commun. 19:6:691-695 (1965).
Beckman et al., Proc. Natl. Acad. Sci. USA, 87:1620-1624 (1990).
Ignarro et al., Proc. Natl. Acad. Sci. USA, 84:9265-9269 (1987).
Hayashi et al., J. Biol. Chem. 241:1:79-884 (1966).
Yonetani et al., J. Biol. Chem. 273:32:20323-20333 (1998).
Eriksson et al., "Binding of Nitric Oxide to Intact Human Erythrocytes as Monitored by Electron Paramagnetic Resonance", BBRC 203 : 176-1811 (1994).
Minamiyama et al., "Effect of Thiol Status on Nitric Oxide Metabolism in the Circulation", Arch. Biochem. Biophys. 3411 : 186-192 (1997).

Affiliated with

Also associated with

Rating

Treatment of hemoglobin with nitric oxide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of hemoglobin with nitric oxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of hemoglobin with nitric oxide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-540665