Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1988-02-24
1990-02-20
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 48, 536 27, 536 28, 536 29, A61K 3170
Patent
active
049026771
ABSTRACT:
A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.
REFERENCES:
patent: 3506643 (1970-04-01), Thiel et al.
patent: 3856776 (1974-12-01), Cehovic et al.
patent: 3915958 (1975-10-01), Shuman et al.
patent: 4058659 (1977-11-01), Robins et al.
Meyer et al, "Synthesis and Biological Activity of Several 6-Substituted 9-.beta.-D-Ribofuranosylpurine 3', 5'-Cyclic Phosphates," Biochemistry, vol. 11, No. 14, (1972), pp. 2704-2709.
Jon P. Miller et al, "Synthesis and Enzymatic and Inotropic Activity of Some New 8-Substituted and 6,8-Disubstituted Derivatives of Adenosine Cyclic 3', 5'-Monophosphate," J. Med. Chem. 1980 23, 242-251.
Lehninger, Biochemistry, Worth Publishers, New York, 1975, pp. 812-815.
Imai Shoichi
Isono Junko
Kataoka Shigehiro
Kato Motohiko
Yamaji Nobuyuki
Crane L. Eric
Griffin Ronald W.
Kikkoman Corporation
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