Treatment of graft versus host disease using a mixture of T-lymp

Details Treatment of graft versus host disease using a mixture of T-lymp Treatment of graft versus host disease using a mixture of T-lymp

1983-01-07

1985-05-28

Padgett, Ben R.

Drug, bio-affecting and body treating compositions

Lymphokine

436548, 435 2, 435 68, 4351722, 435240, 435259, 424 85, 514 8, 935108, A61K 39395, C12N 1500

Patent

active

045202265

ABSTRACT:
A reagent and the protocol for the treatment of Graft Versus Host Disease is disclosed. Monoclonal antibodies specific for T-lymphocytes in human donor bone marrow are covalently linked to separate ricin toxin, combined in a mixture to form a treatment reagent, and combined with bone marrow removed from a human donor. The bone marrow-reagent mixture is then infused into an irradiated recipient. This protocol virtually eliminates T-lymphocyte activity, the cause of Graft Versus Host Disease.

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