Treatment of glial tumors with glutamate antagonists

Details Treatment of glial tumors with glutamate antagonists Treatment of glial tumors with glutamate antagonists

2007-07-31

2007-07-31

Yaen, Christopher H. (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

10225396

ABSTRACT:
The present invention relates to a method of treating glial tumors in a subject, which includes providing a glutamate antagonist or a NMDA receptor antagonist and administering the glutamate antagonist or NMDA receptor antagonist to a subject with a glial tumor of the brain or spinal cord under conditions effective to treat the glial tumor.

REFERENCES:
patent: 4122193 (1978-10-01), Scherm et al.
patent: 5622952 (1997-04-01), Weber et al.
patent: 5776935 (1998-07-01), Danysz et al.
patent: 5830998 (1998-11-01), Maccecchini
patent: 6071970 (2000-06-01), Mueller et al.
patent: 6180613 (2001-01-01), Kaplitt et al.
patent: 6197820 (2001-03-01), Sontheimer et al.
patent: 1 002 535 (2000-05-01), None
patent: WO 00/24395 (2000-05-01), None
patent: WO 00/62771 (2000-10-01), None
Lipton SA (NeuroRx®: The Journal of American Society for Experimental NeuroTherapeutics 2004;1(1):101-110.
Groothius DR Neuro-Oncology 2000;2:45-59.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=mesh&list—uids=68008527&dopt=Full.
Rubin et al (Pathology 2nd Edition, 1994, J.B. Lippincott Company, Philadelphia, pp. 1437-1438).
Rzeski et al., “Glutamate Antagonists Limit Tumor Growth,”PNAS98(11):6372-6377 (2001).
Takano et al., “Glutamate Release Promotes Growth of Malignant Gliomas,”Nature Med. 7:1010-1015 (2001).
Hesselink et al., “The Role of Probenecid-Sensitive Organic Acid Transport in the Pharmacokinetics ofN-Methyl-D-Aspartate Receptor Antagonists Acting at the GlycineB- Site: Microdialysis and Maximum Electroshock Seizures Studies,”J. Pharmacol. Exp. Ther. 290(2):543-550 (1999).
Takano et al., “Glutamate Release Promotes Growth of Malignant Gliomas,”Nature Medicine7(9):1-6 (2001).
Smith et al., “Autoimmune Encephalomyelitis Ameliorated by AMPA Antagonists,”Nature Medicine6(1):62-66 (2000).
Meldrum, “Glutamate and Glutamine in the Brain. Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology,”American Society for Nutritional Sciences(Supp.) 1007S-1015S (2000).
Lee et al., “The Changing Landscape of Ischaemic Brain Injury Mechanisms,”Nature399(Supp.):A7-A14 (1999).
Ye et al., “Glioma Cells Release Excitotoxic Concentrations of Glutamate,”Cancer Research59:4383-4391 (1999).

Affiliated with

Also associated with

Rating

Treatment of glial tumors with glutamate antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of glial tumors with glutamate antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of glial tumors with glutamate antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3722599