Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-05-02
1990-12-04
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548139, C07D285135, A01K 3141
Patent
active
049754467
ABSTRACT:
Method and formulation useful in treatment of glaucoma in a mammal wherein an effective amount of an active water soluble carbonic anhydrase inhibitor is administered, said inhibitor being a compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is selected from the group consisting of H, --OH, --CN and --OCH.sub.3 ; R.sup.2 is hydrogen or a lower alkyl having from one to about 5 carbon atoms; R.sup.3 is selected from the group consisting of HNHCHR.sup.4 --, R.sup.5 NHCHR.sup.4 --, R.sup.5 NHCHR.sup.4, CONHCR.sup.4 --, R.sup.5 NHCH.sub.2 CHR.sup.4 --, ##STR2## R.sup.4 is selected from lower alkyl having from one to about 5 carbon atoms; or a naturally occurring amino acid side chain; and R.sub.5 is selected from the group consisting of H, CH.sub.3 --, HCO--, CH.sub.3 CO-- and XCH.sub.2 CO-- wherein X is a halogen atom; and stereoisomers thereof.
REFERENCES:
March Advanced Organic Chemistry, pp. 370-373 (1985).
Blackburn G. Michael
Trager Seymour F.
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