Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-15
1994-02-22
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548139, C07D285135, A61K 3141
Patent
active
052887359
ABSTRACT:
Method of treating glaucoma in a mammal, comprising administering to the mammal an effective amount of an active water-soluble carbonic anhydrase inhibitor having the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is selected from the group consisting of H, --OH, --CN and --OCH.sub.3, R.sup.2 is methyl or a lower alkyl having from two to about 5 carbon atoms, R.sup.3 is selected from the group consisting of NHCHR.sup.4 --, R.sup.5 NHCHR.sup.4 --, R.sup.5 NHCHR.sup.4 --, ##STR2## R.sup.4 is selected from lower alkyl having from one to about five carbon atoms, or a naturally occurring amino acid side-chain, and R.sup.5 is selected from the group consisting of H, CH.sub.3 --, HCO--, CH.sub.3 CO-- and X--CH.sub.2 CO-- wherein X is a halogen atom and stereoisomers thereof.
REFERENCES:
patent: 5010204 (1991-04-01), Antonaroli et al.
Blackburn G. Michael
Trager Seymour F.
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