Treatment of genital warts with a combination of liquid nitrogen

Details Treatment of genital warts with a combination of liquid nitrogen Treatment of genital warts with a combination of liquid nitrogen

1988-11-01

1990-09-25

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 854, A61K 3766

Patent

active

049592106

ABSTRACT:
Condylomata Acuminata infections (anogenital warts) are treated in infected patients by administering liquid nitrogen and immediately thereafter beginning administering recombinant DNA human alpha interferon thrice a week for three weeks.
The interferon exemplified is recombinant DNA human interferon alfa-2b in which 1.0.times.10.sup.6 International Units are administered by injection to each lesion.
The liquid nitrogen is the cryosurgical agent exemplified and it is topically administered to each lesion by conventional means.

REFERENCES:
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patent: 4503035 (1985-03-01), Pestka et al.
Ghosh, Britain Journal of Venereal Diseases, vol. 53, pp. 49-53, 1977.
Silva et al., J. Am. Acad. & Dermatology, vol. 13, 1985, pp. 457-463.
Eron et al., New Eng. J. Med., vol. 315, pp. 1059-1064, 1986.
Ferenczy et al., The NEJM 313, 784-788 (1985).
Rubenstein, Biochem. Biophys. Acta 695, 5-16 (1982).
Nagata et al., Nature 284, 316-320 (1980).
Smiles et al., The Biology of the Interferon System 1986, Cantell et al., Editor, Dordrecht, Martinus Mijhoff Publishers, 493-501 (1987).
Friedman-Kien et al., JAMA 259, 533-538 (1988).
Gall et al., Obstet Gynecol 67, 643 (1986).

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