Treatment of fungal infections using a combination of an anti-fu

Details Treatment of fungal infections using a combination of an anti-fu Treatment of fungal infections using a combination of an anti-fu

1997-08-08

1999-07-20

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 23, 5142312, 514247, 514315, 514359, 514374, 514396, 514408, 514424, 514460, 424422, A61K 3800, A61K 31535, A61K 3150, A61K 31445

Patent

active

059256168

ABSTRACT:
A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal infection. The N-alkyl heterocyclic compound or salt thereof is present in an amount effective to potentiate or increase the anti-fungal activity of the anti-fungal compound. The N-alkyl heterocyclic compound has the formula: ##STR1## The variable "n" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. A pharmaceutical composition is described where the anti-fungal compound and the N-alkyl heterocyclic compound or salt thereof are present in a combined amount effective to treat a fungal infection. A method for controlling the growth of fungal organisms on various substrates to be inserted into the body using a combined amount of an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof is also described.

REFERENCES:
patent: 5229397 (1993-07-01), Seele et al.
patent: 5250194 (1993-10-01), Hollis et al.
Firestone et al., J. Med. Chem., 30(8), 1519-1521 (1987).
de Savignac et al., Eur. J. Med. Chem., 25(5), 449-454 (1990).
Windholz et al, The Merck Index, 10th Ed. (1983) various antifungal compounds.

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