Treatment of estrogen-receptor positive breast cancer and estrog

Details Treatment of estrogen-receptor positive breast cancer and estrog Treatment of estrogen-receptor positive breast cancer and estrog

1998-06-02

2000-11-21

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514723, 514729, A61K 3112, A61K 3111

Patent

active

061504211

ABSTRACT:
Certain retinoids with CH.sub.2 OH at the side chain terminal position, preferably 4-oxoretinol, inhibit growth of estrogen-receptor positive and estrogen-receptor negative breast cancer tumor cell lines and have utility for adjuvant therapy and treatment of metastatic disease.

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Sheikh et al., "Why are estrogen-receptor-negative breast cancers more aggressive than estrogen-receptor-positive breast cancers?", Invasion and Metastasis, vol. 14/1-6: 329-336, 1994.
Fitzgerald et al., "Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status.", Cancer Research, vol. 57(13): 2642-2650, 1997.
Achkar, C. C., et al., Proc. Nat'l Acad. Sci.USA, vol. 93, pp. 4879-4884, May 1996.
Chen, A. A., et al., Cancer Research 57, 4642-4651 (Oct. 15, 1997).
Hong, W. K., et al., "Retinoids and Human Cancer" in The Retinoids, Biology, Chemistry and Medicine, 2.sup.nd edition, edited by Sporn, M. B., et al., Raven Press Ltd., New York, 1994, pp. 597-630.

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