Treatment of equine protozoal myeloencephalitis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544325, A61K 31505, C07D23948

Patent

active

057474761

ABSTRACT:
The present invention relates to compositions and methods for treating equines, such as horses, afflicted with equine protozoal myeloencephalitis or EPM. The therapeutic compositions comprise a combination of pyrimethamine and a sulfonamide, preferably, sulfadiazine, in the absence of known therapeutic amounts of trimethoprim.

REFERENCES:
patent: 4293547 (1981-10-01), Lewis et al.
patent: 4340609 (1982-07-01), Chou
patent: 4368193 (1983-01-01), Argoudelis et al.
patent: 4599416 (1986-07-01), Kompis
patent: 4728641 (1988-03-01), Tubaro et al.
patent: 4795639 (1989-01-01), Burchall et al.
patent: 4992444 (1991-02-01), Stevens et al.
patent: 5273970 (1993-12-01), McHardy
patent: 5486535 (1996-01-01), Marr et al.
patent: 5506206 (1996-04-01), Kozarich et al.
David S. Lindsay et al., "Evalutation of Anti-coccidial Drugs' Inhibtion of Neospora caninum Development in Cell Cultures," The Journal of Parasitology, Dec. 1989, pp. 990-992.
David S. Lindsay et al., "Demonstration of Synergistic Effects of Sulfonamides and Dihydrofolate Reductase/Thymidylate Synthase Inhibitors Against Neospora caninum Tachyzoites in Cultured Cells, and Characterization of Mutants Resistant to Pyrimethamine," AJVR, vol. 57, Jan. 1996, pp. 68-72.
J.P. Dubey et al., "Anticoccidial Activity of 2-Sulfamoyl-4,4-Diaminodiphenylsulfone, Sulfadiazine, Pyrimethamine and Clindamycin in Cats Infected with Toxoplasma Gondii," The Canadian Veterinary Journal, vol. 18, No. 3, Mar. 1977, pp. 51-57.
Daniel Podzamczer et al., "Twice-weekly, Maintenance Therapy with Sulfadiazine-Pyrimethamine to Prevent Recurrent Toxoplasmic Encephalitis in Patients with AIDS," Annals of Internal Medicine, vol. 123, No. 3, pp. 175-180.
B.T. Nguyen et al., "Comparative Effects of Cotrimoxazole (Trimethoprimsulphamethoxazole), Pyrimethamine-sulphadiazine and Spiramycin During Avirulent Infection with Toxoplasma gondii (Beverley Strain) in Mice," Br. J. Pharmac., vol. 79, 1983, pp. 923-928.
Carol Harris et al., "In Vitro Assessment of Antimicrobial Agents Against Toxoplasma gondii," The Journal of Infectious Diseases, vol. 157, No. 1, Jan. 1988, pp. 14-22.
Harley G. Sheffield et al., "Effect of Pyrimethamine and Sulfadiazine on the Fine Structure and Multiplication of Toxoplasma gondii in Cell Cultures," The Journal of Parasitology, vol. 61, No. 4, Aug. 1975, pp. 704-712.
I.G. Mayhew, "Large Animal Neurology: A Handbook for Veterinary Clinicians," Lee & Febiger, Philadelphia, 1989, pp. 279-285.
Bruce G. Gellin et al., "Coccidian Infections in AIDS: Toxoplasmosis, Cryptosporidiosis, and Isosporiasis," The Medical Clinics of North America, vol. 76, No. 1, Jan. 1992, pp. 206-234.
Clara K. Fenger et al., "Identification of Opossums (Didelphis virginiana) as the Putative Definitive Host of Sarcocystis Neurona," Journal of Parasitology, vol. 81, No. 6, Dec. 1995, pp. 916-919.
"Treatment of Equine Protozoal Myeloencephalitis" by Barbara Brewer Welsch, MA, DVM. et al. The Compendium North American Edition.Equine, 1599-1602, 1991.
"Equine Protozoan Encephalomyelitis" by Jill Beech, V.M.D. Veterinary Medicine/Small Animal Clinician, Dec. 1974, 1562-1566.
"Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Bverely strain) in mice" by B.T. Nguyen et al., Br. J. Pharmac. (1983), 79, 923-928.
3615 Eriodictyon, The Merck Index, (1989) p. 530.
7997 Pyrimethamine, The Merck Index, (1989) p. 1270.
8874 Sulfadiazine, The Merck Index, (1989) p. 1404.
15-Pharmacodynamics, vol. 69, 1968, p. 4749, Sec. 50900p.
Chemical Abstracts, vol. 85, 1976, pp. 46-47, Sec. 72303d.
1-Pharmacodynamics, vol. 78, 1973, p. 31, Sec. 52708s.
1-Pharmacodynamics, vol. 77, 1972, p. 14, Sec. 109339h.
1-Pharmacodynamics, vol. 92, 1980, p. 63, Sec. 92:15581p.
Chemical Abstracts, vol. 87, 1977, p. 60, Sec. 87:95742b.
Chemical Abstracts, vol. 101, 1984, p. 352, Sec. 101:87339t.
Chemical Abstracts, vol. 99, 1983, p. 20, Sec. 99:133330y.
63-Pharmaceuticals, vol. 96, 1982, p. 373, Sec. 96:40845t.
1-Pharmacology, vol. 123, 1995, p. 37, Sec. 123:102131u.
Chemical Abstracts, vol. 123, 1995, p. 38, Sec. 123:74277a.
Chemical Abstracts, vol. 122, 1995, p. 570, Sec. 122;235089n.
Chemical Abstracts, vol. 122, 1995, p. 44, Sec. 122:45806w.
1-Pharmacology, vol. 120, 1994, p. 33, Sec. 120:45263a.
1-Pharmacology, vol. 118, 1993, p. 29, Sec. 118:182836n.
"Pharmacokinetics of intravenously and orally administered pyrimethamine in horses" by Cyril R. Clarke, BVSc, Ph.D. et al., Am. J. Vet. Res. vol. 53, No. 12, Dec. 1992.
"Pharmacokinetics, penetration into cerebrospinal fluid, and hematologic effects after multiple oral administrations or pyrimethamine to horses", by Cyril R. Clarke, BVSc, Ph.D. et al., Am. J. Vet. Res., vol. 53, No. 12, Dec. 1992.
"In Vitro Effects of Sulfadiazine and Its Metabolites Alone and in Combination with Pyrimethamine on Toxoplasma gondii" by Esther Schoondermark-Van De Ven et al., Antimicrobial Agents and Chemotherapy, Mar. 1995, vol. 39, No. 3, pp. 763-765.
"New Micromethod to Study the Effect of Antimicrobial Agents on Toxoplasma gondii: Comparison of Sulfadoxine and Sulfadiazine Individually and in Combination with Pyrimethamine and Study of Clindamycin, Metronidazole, and Clyclosporin A" by D.G. Mack et al., Antimicrobial Agents and Chemotherapy, Jul. 1984, vol. 26, No. 1, pp. 26-30.
EPM Seminar, The Horse, Nov. 1995, pp. 14-23.
"Equine Protozoal Myelitis Workshop: Summary for the Horseman" Grayson Jockey Club Research Foundation EPM Seminar, Mar. 8, 1996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of equine protozoal myeloencephalitis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of equine protozoal myeloencephalitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of equine protozoal myeloencephalitis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-54741

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.