Treatment of endotoxin-associated disorders with cationic peptid

Details Treatment of endotoxin-associated disorders with cationic peptid Treatment of endotoxin-associated disorders with cationic peptid

1996-03-13

1997-11-18

Patterson, Jr, Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 697, 4352521, A61K 3816

Patent

active

056887671

ABSTRACT:
A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.

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