Treatment of endotoxic shock

Details Treatment of endotoxic shock Treatment of endotoxic shock

1997-01-27

2000-01-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

514893, A61K 968

Patent

active

060132736

ABSTRACT:
The invention provides a method for the treatment of endotoxic shock comprising administering to a human or other mammal in need of such a treatment an effective amount of choline for reducing endotoxin-induced injury and mortality and a nutritional composition comprising choline, whereby the composition provides a daily dosage of at least 1.5 g choline, the upper limit being 20 g of choline per day.

REFERENCES:
patent: 5374651 (1994-12-01), Kilbourn et al.
Malone et al., Excerpta Medica (EMBASE), #94077814, 1995.
Altura BM, et al. (1966). "Influence of Choline on the Reticuloendothelial System and on Survival after Experimental Shock", vol. 3, No. 1, p. 57-64.
List PH, et al. (1972). "Hagers Hanbuch Der Pharmazeutischen Praxis, 4th D., vol. 3" p. 885-890. (*Copies not provided.).
Malone M, et al., (1994). "Long-term Hyperalimentation", Curr Opin Gastroenterol, vol. 10, No. 2, p. 227-234.
Reichard SM, (1972). "RES Stimulation and Transfer of Protection Against Shock", vol. 12, No. 6.
Reynolds JEF, (1996). "Martindale the Extra Pharmacopoeia" p. 1356-1357.
Lieber et al., Phosphatidylcholine Protects Against Fibrosis and Cirrhosis in the Baboon, Gastroenterology 1994; 106:152-159.
Bread et al., Triglyceride-rich Lipoproteins Prevent Septic Death in Rats, 1995 vol. 182 pp. 1-1066.
Harris et al., Human Very Low Density Lipoproteins and Chylomicrons can Protect Against Endotoxin-induced Death in Mice, vol. 86, Sep. 1990, 696-702.
Feingold et al., Role for Circulating Lipoproteins in Protection from Endotoxin Toxicity, vol. 63, No. 5, Infection and Immunity, May 1995, p. 2041-2046.
Ikejima et al., A diet containing glycine improves survival in Endotoxin shock in the rat, 1996, vol. 271 No. 1, Part 1, pp. G97-G103.

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