Treatment of E. faecium infection

Details Treatment of E. faecium infection Treatment of E. faecium infection

2005-04-19

2005-04-19

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S093200, C424S163100, C424S164100, C424S234100, C530S388400, C530S389500

Reexamination Certificate

active

06881410

ABSTRACT:
The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic and diagnostic use, together with diagnostic test methods, methods of same and kits for performing same. Also provided are immunodominant conserved antigens from gram positive staphylococci, together with neutralising and binding agents specific thereto for use in therapy and diagnosis, and methods of same. Also provided are Staphylococcal holomogues of IstA and IstB and immunogenic fragments thereof, and their uses in methods of treatment and diagnosis of the human or animal body.

REFERENCES:
patent: 5747239 (1998-05-01), Wang et al.
patent: WO 9306247 (1993-04-01), None
patent: WO 9520658 (1995-08-01), None
Ristori et al. Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens. FASEB Journal (2000) vol. 14, No. 3, pp. 431-438.*
Casadevall et al. Return to the Past: The case for antibody-based therapies in infectious diseases. Clinical Infectious Diseases (1995) vol. 21, pp. 150-161.*
Paul W.E.(Fundamental Immunology, Raven Press, New York, NY; (1993) 3rd Edition, p. 249, 251.*
Klein Self-nonself discrimination, histoincompatibility, and the concept of immunology. Immunogenetics (1999) vol. 50, No. 3-4, pp. 116-123.*
I.M. Clark et al., “Isolation and sequence determination of an immunodominant antigen fromenterococcus faecalis” Serodiagnosis & Immunotherapy in Infectious Disease, vol. 5, No. 2, Jul. 1993, pp. 85-92.
A. Sulaiman et al., “Serological investigation of enterococcal infections using western blot” European Journal of Clinical Microbiology & Infectious Diseases, vol. 5, No. 10, Oct. 1996, pp. 826-829.
M.J. Fath et al., “ABC Transporters bacterial exporters” Microbiological Reviews, vol. 57, No. 4, Dec. 1993, pp. 995-1017.
M. Frosch et al., “Conserved outer membrane protein of neisseria meningitidis involved in capsule expression” Infection and Immunity, vol. 60, No. 3, Mar. 1992, pp. 798-803.
M. Frosch et al. “Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsularpolysaccharides.” Molecular Microbiology, vol. 5, No. 5, 1991, pp. 1251-1263.
Gillmore et al. “An HlyB-type function is required for expression of theEnterococcus faecalishemolysisn/bacteriocin.” Infection and Immunity. vol. 58, No. 12, 1990, pp. 3914-3923.
Weisman et al. “Intravenous immune globulin prophylaxis of late-onset sepsis in premature neonates.” Journal of Pediatrics, vol. 124, 1994, pp. 922-930.
J. Klein, “Self-nonself discrimination, histocompatibility, and the concept of immunology.” Immunogenetics, vol. 50, 1999, pp. 116-123.
W. Paul. “Fundamental Immunology.” Raven Press, ltd. New York, NY, 1993, pp. 249-251.
Ristori et al. “Compositional bias and mimicry toward the nonself proteome in immunodominant T cell epitopes of self and nonself antigens.” FASEB Journal, vol. 14, 2001, pp. 431-438.
A. Casadevall et al. “Return to the past: the case for antibody-based therapies in infectious diseases.” Clinical Infectious Diseases, vol. 21, 1995, pp. 150-161.

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