Treatment of dysfunctional vascular endothelium using activated

Details Treatment of dysfunctional vascular endothelium using activated Treatment of dysfunctional vascular endothelium using activated

1987-12-31

1991-04-23

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514 2, 435219, 435226, A61K 37547, A61K 3702

Patent

active

050098896

ABSTRACT:
A pharmaceutical composition comprising activated protein C activity is used to treat subjects for permeability and coagulopathic dysfunctions of vascular endothelial cells in response to an inflammatory stimulus. The composition may be used to prevent or to reverse these pathological events. Further, the composition is used to prevent elevated plasma levels of tumor necrosis factor, an inflammatory mediator which participates in the chain of events which produce the dysfunctional responses.

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