Treatment of diseases involving faulty MHC class I antigen...

Details Treatment of diseases involving faulty MHC class I antigen... Treatment of diseases involving faulty MHC class I antigen...

2006-01-10

2006-01-10

Wehbe, Anne Marie S. (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093200, C424S193100, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

06984380

ABSTRACT:
Methods of treating autoimmune diseases, such as diabetes, characterized by faulty MHC class I antigen complex presentation are disclosed which involve exposure of the immune system of an individual susceptible to such disease to correctly associated MHC class I antigen complexes. Such treatment may involve obtaining cells from the individual, treating the cells to correct faulty MHC class I antigen presentation, then reinfusing the treated cells. Alternatively, syngeneic or haplotype-matched allogeneic lymphoid cells expressing normal levels of MHC class I antigen complexes may be used or intact MHC class I antigen complexes isolated from such lymphoid cells may be used in such treatment.

REFERENCES:
patent: 4946674 (1990-08-01), von Eichborn et al.
patent: 5635363 (1997-06-01), Altman et al.
patent: WO 90/10016 (1990-09-01), None
Jacob et al. (1990) PNAS, vol. 87, 968-972.
Eck and Wilson (1996) Pharm. Basis of Therapeutics. Chapter 5, pp. 77-101.
Ledley (1996) Pharm. Res., vol. 13, 1595-1614.
Ledley, (1991) Human Gene Therapy, vol. 2, 77-83.
Verma et al. (1997) Nature, vol. 389, 239-242, 1997.
Marshall et al. (1995) Science, vol. 269, 1050-1055, 1995.
Orkin et al. (1995) “Report and Recommendations of the Panel . . . ”, 1995.
Kalden et al. (1998) Advances in Immunology, vol. 68, 396-401, 1997.
Bikoff et al Nature 354 : 235, 1991.
Spies et al Nature 348 : 744, 1990.
Festenstein et al Nature 322 64, 1986.
Trowsdale et al Nature 348 741, 1990.
Selden et al Seminars in Medicine 317(17) : 1067, 1987.
Spies et al Nature, 355: 644, 1992.
Van Bleek et al Nature 348 213, 1990.
Berkos et al., File Server STN Karlsruhe, File Medline Abstract No. 90231955,Probl. Endokrinol., (Mosk), 36(1): 3-8 (Jan.-Feb. 1990).
Bikoff et al.,Nature, 354: 235-238 (1991).
Cohen et al.,Immunol. Rev., 85: 87-105 (1985).
Faustman et al.,Diabetes, 38: 1462-1468 (1989).
Festenstein et al.,Nature, 322: 64-67 (1986).
Foulis et al.,Diabetes, 35: 1215-1224 (1986).
Gony et al.,Tissue Antigens, 31: 229-234 (1988).
Hattori et al.,Science, 231: 733-735 (1986).
Kelly et al.,Nature, 353: 667-668 (1991).
Konekov et al., File Server STN Karlsruhe, Medline Abstract No. 88278232,Ter. Arkh., 60(4): 86-89 (1988).
Lawlor et al.,Annu. Rev. Immunol., 8: 23-63 (1990).
Leiter et al.,Clin. Immunol.&Immunopath., 59:323-334 (1991).
Madden et al.,Nature, 353: 321-325 (1991).
Miller et al.,Immunol. Today, 10(2): 53-57 (1989).
Raum et al.,J. Clin. Invest., 74: 449-454 (1984).
Rossini et al.,J. Clin. Invest., 74: 39-46 (1984).
Rudensky et al.,Nature, 353:622-627 (1991).
Selden et al.,Seminars in Medicine, 317(17) 1067-1076 (1987).
Serreze et al.,J. Immunol., 140: 3801-3807 (1988).
Spies et al.,Nature, 351: 323-324 (1991).
Tananov et al., File Biosis Abstract No. 82:259448,Probl. Gematol. Pereliv. Krovi., 26(1): 8-12 (1981).
Trowsdale et al.,Nature, 348: 741-744 (1990).
Van Bleek et al.,Nature, 348: 213-216 (1990).
Amrani et al.,Nature, 406(6767): 739-742 (2000).
Bouvier et al.,Science, 265: 398-402 (1994).
Chang et al.,J. Immunol., 137: 2853-2856 (1986).
Collins et al.,PNAS USA, 83: 446-450 (1986).
Eisenbarth & Kotzin,J. Clin. Invest., 111(2): 179-181 (2003).
Ferlin et al.,Current Opinion in Immunology, 12: 670-675 (2003).
Pujol-Borrell et al.,Nature, 326: 304-306 (1987).

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