Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1991-07-26
1994-07-12
Rosenbaum, C. Fred
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 96, 606194, A61M 2900
Patent
active
053284704
ABSTRACT:
A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
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Nabel Elizabeth G.
Nabel Gary J.
Alexander V.
Rosenbaum C. Fred
The Regents of the University of Michigan
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