Treatment of disease states induced by oxidative stress

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436829, A61K 9127, A61K 9133

Patent

active

056373155

ABSTRACT:
Liposome carrier systems, methods and pharmaceutical compositions that target an organ preferentially with high concentrations of at least one therapeutic agent utilize a liposome carrier having a lipid membrane and an aqueous space to deliver pharmacologically active agents, such as free radical scavengers and antioxidants, to a target organ such as the liver. At least one free radical scavenger and/or antioxidant and a liposome carrier may be provided to a liver donor prior to harvesting to preserve the liver for transplantation.

REFERENCES:
patent: 4952409 (1990-08-01), Bando
patent: 5047395 (1991-09-01), Wu
patent: 5162366 (1992-11-01), Kimoto
patent: 5262168 (1993-11-01), Leuk
Dai Nakae et al., "Liposome-Encapsulated Superoxide Dismutase Prevents Liver Necrosis Induced by Acetaminophen", Amer. Journ. of Pathology 1990, 136(4), 787-795.
Liu and Huang, "Size Homogeneity of a Liposome Preparation is Crucial for Liposome Biodistribution in Vivo", J. Liposome Res. 1992, 2, 57-66.
Motoyama, T. et al., "Synergistic Inhibition of Oxidation in Dispersed Phosphatidylcholine Liposomes by a Combination of Vitamin E and Cysteine", Archives of Biochemistry and Biopohysics 1989, 270(2), 655-661.
Pak H. Chan, "Antioxidant-Dependent Amelioration of Brain Injury: Role of CuZn-Superoxide Dismutase", Journ. Neutro. 1992, 9, S417-S423 Supplement 2.
Poznansky, M. and Juliano, "Biological Approaches to the Controlled Delivery of Drugs: A Critical Review", Pharmacological Reviews 1984, 36(4), 277-336.
Roerdink et al., "The Involvement of Parenychmal, Kupffer, and Endothelial Liver Cells in the Hepatic Uptake of Intravenously Injected Liposomes", Biochemica et Biophysica Acta 1986, 863, 224-230.
Scherphaf et al., "Targeting of Liposomes to Liver Cells" in Drug Carrier Systems, Roerdink and Koon, eds., pp. 281-291, John Wiley & Sons, Ltd., 1989.
Spanjer et al., "Intrahepatic Distribution of Small Unilamellar Liposomes as a Function of Liposomal Lipid Composition", Biochemica et Biophysica Acta 1986, 677, 79-89.
Thibeault et al., "Prevention of Chronic Pulmonary Oxygen Toxicity in Young Rats with Liposome-Encapsulated Catalase Administered Intratracheally", Pediatric Pulmonology, 11:318-327 (1991).
Pelle, Vitamin E: Biochemistry and Health implications, vol. 570, p. 491, 1989.
Packer, Proc. Soc. Exper. Biol., vol. 220, p. 271, 1992.
Poznansky, Pharmacological Reviews, 36, 1984, p. 227.
Motoyama ABB, 270 #2, p. 655, 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of disease states induced by oxidative stress does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of disease states induced by oxidative stress, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of disease states induced by oxidative stress will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-763026

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.