Treatment of diabetes with 2-substituted-1,3-diazacyclic compoun

Details Treatment of diabetes with 2-substituted-1,3-diazacyclic compoun Treatment of diabetes with 2-substituted-1,3-diazacyclic compoun

1976-06-25

1979-01-23

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260239BC, 2602444, 424241, 424251, 424263, 424266, 544242, 544330, 544331, 544333, 544335, 546278, A61K 31415

Patent

active

041361881

ABSTRACT:
2-SUBSTITUTED-1,3-DIAZACYCLIC COMPOUNDS OF THE FORMULA: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.2 represents a hydrogen atom, a lower alkoxycarbonyl group, an aliphatic acyl group or an aromatic acyl group, the aromatic ring of which may have one or more substituents selected from a halogen atom, a lower alkyl group, a lower alkoxy group, an acyl group and an acyloxy group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or an aralkyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group or an aryl group; R.sub.6 represents a cyclohexyl group, a pyridyl group or a phenyl group which may have a substituent selected from a halogen atom, a lower alkyl group and a lower alkoxy group; A represents -N.dbd., an -N(lower alkyl)- group or a methylene group; n represents an integer of from 2 to 4, and a dotted line indicates that a double bond is optional; salts of such derivatives; and the method for preparing such compounds and their salts; the compounds and their salts having a distinct anti-diabetic activity in humans and animals.

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Faust et al., J. Org. Chem., 1961, vol. 26, pp. 4044-4047.
Harsanyi et al., Chem. Abst., 1964, vol. 61, col. 5660.
Jilek et al., J. Chem. Soc. (London), 1950, pp. 188-190.
Pirvu Chem. Abst., 1971, vol. 75, No. 118270q.
Walter Chem. Abst. 1970, vol. 72, No. 31790y.

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