Treatment of diabetes using phosphorylated insulin

Details Treatment of diabetes using phosphorylated insulin Treatment of diabetes using phosphorylated insulin

1991-05-30

1993-09-07

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530303, 530305, A61K 3726, C07K 312, C07K 328

Patent

active

052429008

ABSTRACT:
Phosphorylated insulins which can be prepared from chemically extracted pharmacological insulins by gentle treatment with phosphorus oxychloride, have been shown to have reduced bioactivity by mouse convulsion assay, but such phosphorylated insulins reduce hyperglycemia when administered to diabetic subjects without inducing hypoglycemia.

REFERENCES:
patent: 3869437 (1975-03-01), Lindsay et al.
patent: 4705845 (1987-11-01), Cerami et al.

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