Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1994-02-28
1999-01-19
Rollins, John W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 184, 4241301, 4241951, 514 2, 514866, C12Q 142, C12N 999, A61K 39395, A61K 3578
Patent
active
058612661
ABSTRACT:
The present invention relates to novel modalities of treatment of diabetes, and other diseases caused by dysfunctional signal transduction by insulin receptor type tyrosine kinases (IR-PTK). Applicants discovered that IR-PTK activity may be modified by modulating the activity of a tyrosine phosphatase, and IR-PTK signal transduction may be triggered even in the absence of ligand. Methods for identifying compounds that, by modulating RPTP.alpha. or RPTP.epsilon. activity, elicit or modulate insulin receptor signal transduction are also described.
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Kharitonenkov Alexei Igorevich
Lammers Reiner
Sap Jan M.
Schlessinger Joseph
Ullrich Axel
Max-Planck-Gesellschaft zur Forderung der Wissenshaften e.V.
New York University
Rollins John W.
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