Treatment of conditions requiring enhanced oxygen availability t

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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Details

514569, 514561, 514567, A61K 3121, A61K 3119, A61K 31195

Patent

active

048617954

ABSTRACT:
Disclosed are pharmaceutical compositions containing naphthoic acid derivatives and method of use for enhancing oxygen availability to mammailian tissue.

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patent: 4626432 (1986-12-01), Hyde et al.
patent: 4774088 (1988-09-01), Vora
Teisseire et al., "Long-Term Physiological Effects of Enhanced O.sub.2 Release by Inositol Hexaphosphate-Loaded Erythrocytes"; Proc. Natl. Acad. Sci, U.S.A., vol. 84, pp. 6894-6898, Oct. 1987.
Pendelton et al., "Effect of Propranolol Upon the Hemoglobin-Oxygen Dissocation Curve", The Journal of Pharmacology and Experimental Therapeutics, vol. 180, No. 3, pp. 647-656, 1971.
Gross et al., "Effect of Ortho-Iodo Sodium Benzoate on Hemoglobin-Oxygen Affinity in Normal and Ischemic Myocardium", The Journal of Pharmacology and Experimental Therapeutics, vol. 202, pp. 72-81, 1977.
Perutz et al., "Benzafibrate Lowers Oxygen Affinity of Haemoglobin", The Lancet, pp. 881-882.
Hyde et al., "Modification of the Haemoglobin Oxygen Dissociation Curve in Whole Blood by a Compound with Dual Action", The Lancet, pp. 15-16, Jul. 1984.
Patterson et al., "Xanthone Additives for Blood Storage that Maintain Its Potential for Oxygen Delivery", Transfusion, vol. 28, No. 1, pp. 34-37, 1988.

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