Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Acyclic nitrogen double bonded to acyclic nitrogen – acyclic...
Patent
1988-07-25
1989-07-18
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...
514814, 514866, 514921, A61K 31655
Patent
active
048494160
ABSTRACT:
Disclosed are pharmaceutical compositions containing certain heterocylcic sulphonamido azo compounds for enhancing oxygen availability to mammalian tissue.
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Teisseire et al., "Long-Term Physiological Effects of Enhanced O.sub.2 Release by Inositol Hexapahosphate-Loaded Erythrocytes"; Proc. Natl. Acad. Sci. USA, vol. 84, pp. 6894-6898, Oct. 1987.
Pendleton et al., "Effect of Propranolol Upon the Hemoglobin-Oxygen Dissociation Curve", The Journal of Pharmacology and Experimental Therapeutics, vol. 180, No. 3, pp. 647-656, 1971.
Gross et al., "Effect of ortho-Iodo Sodium Benzoate on Hemoglobin-Oxygen Affinity in Normal and Ischemic Myocardium", The Journal of Pharmacology and Experimental Therapeutics, vol. 202, pp. 72-81, 1977.
Perutz et al., "Benzafibrate Lowers Oxygen Affinity of Haemoglobin", The Lancet, pp. 881-882.
Hyde, et al., "Modification of the Haemoglobin Oxygen Dissociation Curve in Whole Blood by a Compound with Dual Action", The Lancet, pp. 15-16, Jul. 1984.
Patterson et al., "Xanthone Additives for Blood Storage that Maintain its Potential for Oxygen Delivery", Transfusion, vol. 28, No. 1, pp. 34-37, 1988.
Herczeg Tihamer
Menard Paul R.
Pendleton Robert G.
Pendley, II Charles E.
Suh John T.
Henley III Raymond J.
Robinson Douglas W.
Rorer Pharmaceutical Corporation
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