Treatment of cocaine abuse using N-substituted derivatives...

Details Treatment of cocaine abuse using N-substituted derivatives... Treatment of cocaine abuse using N-substituted derivatives...

2007-11-06

2007-11-06

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

11029247

ABSTRACT:
The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective κ agonists. The invention includes a number of new compounds having both nonselective κ opioid receptor agonist activity and additional activity at μ opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.

REFERENCES:
patent: 3767658 (1973-10-01), Atsumi et al.
patent: 3917606 (1975-11-01), Merz et al.
patent: 4767718 (1988-08-01), Meyers
patent: 4806341 (1989-02-01), Chien et al.
patent: 4992445 (1991-02-01), Lawter et al.
patent: 5506359 (1996-04-01), Madras et al.
patent: 5770180 (1998-06-01), Madras et al.
patent: 6004962 (1999-12-01), Gooberman
patent: 6156769 (2000-12-01), Farrar et al.
patent: 6174891 (2001-01-01), Nagase et al.
patent: WO 94/04146 (1994-03-01), None
patent: WO 97/40859 (1997-11-01), None
Kuzmin et al, European Neuropsychopharmacolgy, vol. 10 p. 447-454 (2000).
Toll et al, NIDA Research Monograph, Volume Date 1997, 178 (problems of Ddrug Dependence, 1997), p. 440-466 (1998).
“Apomorphine: New Uses for an Old Drug” Neumeyer and Baldessari, et al., Pharmaceutical News, vol. 4, No. 6, pp. 12-16, 1997.
“Dopamine Transporter Imaging with Florine-18-FPCIT and PET” Kazumata, et al., The Journal of Nuclear Medicine, vol. 39, No. 9, pp. 1551-1530, Sep. 1998.
“Kappa Opioid Agonists as Targets for Pharmacotherapies in Cocaine Abuse” Neumeyer, et al., Pharmaceutica Acta Helvetiae 74, pp. 337-344, 2000.
“Synthesis and Opioid Receptor Affinity of Morphinan and Benzomorphan Derivatives: Mixed κ Agonists and μ Agonists/Antagonists as Potential Pharmacotherapeutics for Cocaine Dependence” Neumeyer, et al., Journal of Medicinal Chemistry, vol. 43, No. 1, pp. 114-122, 2000.

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