Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514215, 540578, 546118, A61K 31435, C07D47104

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active

050913905

ABSTRACT:
Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.

REFERENCES:
patent: 4812462 (1989-03-01), Blankley et al.
John M. Morgan, "Angiotensin Injected into the Neostriatum After Learning Disrupts Retention Performance" Apr. 1977, pp. 87-89 Science vol. 196.
B. A. Scholkens, W. Jung, W. Rascher, R. Dietz and D Ganten, "Intracerebroventricular angiotensin II increases arterial blood pressure in rhesus monkeys by stimulation of pituitary hormones and the sympathetic nervous system", Jul. 15, 1981, pp. 469-470.
Steven Whitebread, Michele Mele, Bruno Kamber and Marc de Gasparo, "Preliminary Biochemical Characterization of Two Angiotensin II Receptor Subtypes", Aug. 1989, pp. 284-291, Biochemical and Biophysical Research Communications.
James P. Bennett, Jr. and Solomon H. Snyder, "Angiotensin II Binding to Mammalian Brain Membranes", Dec. 1976, pp. 7423-7430, The Journal Of Biological Chemistry, vol. 251, No. 23.
Chiu et al., "Identification of Angiotensin II Receptor Subtypes", Nov. 1989, pp. 196-203, Biochemical and Biophysical Research Communications, vol. 165, No. 1.
Barnes et al., "Angiotensin II inhibits the release of [.sup.3 H] acetylcholine from rat entorhinal cortex in vitro", 1989, pp. 136-143.
Costall et al., "The Effects of ACE Inhibitors Captopril and SQ29,852 in Rodent Tests of Cognition", 1989, pp. 573-579.
Usinger et al., "Indications on the Memory-Enhancing Effects of a Peptidase Inhibitor", 1988, pp. 315-324.
Arregui et al., "Angiotensin Converting Enzyme in Alzheimer's Disease Increased Activity in Caudate Nucleus and Cortical Areas", 1982, pp. 1490-1492, Journal of Neuro Chemistry.
Koller et al., "Endogenous Brain Angiotensin II Disrupts Passive Avoidance Behavior In Rats", 1979, pp. 71-75.
Unger et al., "Brain angiotensin: pathways and pharmacology", 1988, pp. 140-154.
J. F. E. Mann, "Brain Angiotensin II Receptors: Possible Physiological Implications", 1982, pp. 242-254.
James T. Fitzsimons, "Angiotensin Stimulation of the Central Nervous System", 1980, pp. 117-167, Rev. Physiol. Biochem. Pharmacol., vol. 87.
Zubenko et al., "Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme, Acetylcholinesterase, and Dopamine Metabolites in Dementia Associated with Alzheimer's Disease and Parkinson's Disease; A Correlative Study", 1986, pp. 1365-1381.
Koller et al., "Endogenous Brain Angiotensin II Disrupts Passive Avoidance Behavior In Rats", 1979, pp. 71-75.

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