Treatment of chronic obstructive pulmonary disease (COPD) by inh

Details Treatment of chronic obstructive pulmonary disease (COPD) by inh Treatment of chronic obstructive pulmonary disease (COPD) by inh

1991-11-27

1993-10-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

514393, 514398, 514399, 514401, 514402, 514826, 514851, A61L 904

Patent

active

052502864

ABSTRACT:
A method of using an imidazoline compound, which is a vasodilator and an alpha-adrenergic blocking agent, for the treatment of symptoms of chronic obstructive pulmonary diseases (COPD), including cystic fibrosis, chronic bronchitis and emphysema, or COPD where it is associated with asthma, comprises administering the imidazoline to a patient by inhalation. Preferably, the imidazoline compound employed is tolazoline. The presentation of an imidazoline compound in a device for the administration of an aerosol is disclosed.

REFERENCES:
patent: 2161938 (1939-06-01), Sonn
patent: 4255439 (1981-03-01), Cooper
Kelminson et al. "The Reversibility of Pulmonars Hypotension in Patients with Cystic Fibrosis", Pediatrics 1967 vol. 39(1) 24-35.
Feather et al. "Effect of Tolazoline Hydrochloride on Sputum Viscosity in Cystic Fibrosis" Thorax (1970) No. 25 pp. 732-736.
Gross, et al., Chest, 66, 397 (1974).
Scholz, Industrial and Engineering Chemistry, 37, 120 (1945).
Gennaro, Ed., Remington's Pharmaceutical Sciences, 17th Edition, 1672-1675, 1834-1835 (1985).
Waldon, et al., Am. Rev. Respir. Dis., 130, 357 (1984).
Barnes, et al., J. of Allergy and Clinical Immunology, 68, 411 (1981).
Cotton, E. K., "Tolazoline in the Treatment of Cystic Fibrosis," The Society for Pediatric Research Program and Abstracts of the 36th Annual Meeting, p. 51 (1966).

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