Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1985-07-05
1986-12-23
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3119
Patent
active
046312943
ABSTRACT:
A method of treating a victim suffering from cerebral ischemia or treating a patient expected to suffer an ischemic insult comprises administering a therapeutically effective amount of a dichloroacetate. The post-treatment occurs within about 48 hours of the ischemic insult and lasts for up to about two days.
REFERENCES:
patent: 3179562 (1965-04-01), Hoffman
patent: 4122188 (1978-10-01), Stacpoole
Treatment of Lactic Acidosis with Dichloroacetate in Dogs; The Journal of Clinical Investigation; vol. 70; Oct. 1982; pp. 853-862.
Effects of Dichloroacetate on Brain Tissue Pyruvate Dehydrogenase; Journal of Neurochemistry; vol. 41, Nov. 4, 1983; pp. 1052-1056.
Effects of Dichloroacetate on Brain Pyruvate Dehydrogenase; Journal of Neurochemistry; vol. 42; Nov. 1, 1984; pp. 38-42.
Metabolic Effects and Pharmacokinetics of Intravenously Administered Dichloroaetate in Humans; Diabetologia; Spring 1980; pp. 109-113.
The Metobolic Effects of Dichloroacetate; Metabolism; vol. 30, No. 10, Oct. 1981; pp. 1024-1039.
Dichloroacetate Tissue Concentrations and Its Relationship to Hypolactatemia and Pyruvate Dehydrogenase Activation; Biochemical Pharmacology; vol. 31, Nov. 19, 1982; pp. 3124-3126.
Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and Hyperlipoproteinemia; New England Journal of Medicine; Mar. 9, 1978; pp. 526-530.
Toxicity of Chronic Dichloroacetate; New England Journal of Medicine; Feb. 15, 1979; p. 372.
Metabolic Effects of Sodium Dichloroacetate in Normal and Diabetic Dogs; Diabetes; vol. 28, Sep. 1979; pp. 852-857.
Biological Disposition of Sodium Dichloroacetate in Animals and Humans after Intravenous Administration; The Journal of Pharmaceutical Sciences; Apr. 1980; pp. 419-421.
Treatment of Lactic Acidosis with Dichloroacetate; New England Journal of Medicine; Aug, 18, 1983; vol. 309, No. 7; pp. 390-396.
Friedman Stanley J.
University E.M., Inc.
Wilson Charles R.
LandOfFree
Treatment of cerebral ischemia with dichloroacetate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of cerebral ischemia with dichloroacetate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of cerebral ischemia with dichloroacetate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-172009