Treatment of cerebral edema with ANP pharmaceutical compositions

Details Treatment of cerebral edema with ANP pharmaceutical compositions Treatment of cerebral edema with ANP pharmaceutical compositions

1989-11-13

1993-04-20

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, A61K 3702, C07K 710

Patent

active

052043274

ABSTRACT:
A pharmaceutical composition and its use in the treatment of cerebral edema are provided wherein the composition comprises an atrial natriuretic peptide having an amino acid sequence of 28 amino acids and at least one pharmaceutically acceptable carrier, diluent or excipient.

REFERENCES:
patent: 4663437 (1987-05-01), de Bold
Doczi et al. Neurosurgery, vol. 21, #4, Oct. (1987) pp. 454-458.
Doczi et al. Acta Neurochirurgica, vol. 43, Supplement 43, 1980, pp. 186-458.
Klatzo, I., "Neuropathological aspects of brain edema," J. Neuropath, Exp. Neurol., 26, 1-14 (1967).
Fishman, R. A., "Brain edema," New England J. Med., 293, 706-(1975).
Marc Cantin and Jacques Genest, "The Heart as an Endocrine Gland," Scientific American, 254, 62-67 (1986).
Bianchi, C., et al., "Radiautographic Localization of .sup.125 I-Atrial Natriuretic Factor Binding Sites in the Brain," Neuroendocrinology, 44 365-372 (1986).
Steardo, L. and Nathanson, J. A., "Brain Barrier Tissues: End Organs for Atriopeptins," Science, 235, 470-473 (1987) p. 11.
Watanabe et al., Eur. J. Pharmacol., 147, 49-57 (1988).
Imai, T. et al., "Effect on ANP on kidney," Protein-Nucleic Acid-Enzyme, 113 (14), 2476-2489 (1988).

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