Treatment of cellular proliferative disorders with...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07994126

ABSTRACT:
Disclosed are compositions comprising Hom polypeptide (also known as Xom, Ventx2) and methods for treating cellular proliferative disorders comprising. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods.

REFERENCES:
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XP002557883 Arseni et al.; “The vent-like homeobox gene VENTX2 is a novel candidate for a human hematopoietic regulatory protein” Annals of Hematology; vol. 85, No. Suppl 1., Feb. 2006 p. 18.
XP002557884 Database EMBL Sequence 401 from Patent W020044076622, Sep. 27, 2004.
XP002557886 Moreau-Aubry et al; A processed pseudogene codes for a new antigen recognized by a CD8<+> T cell clone on melanoma; Journal of Experimental Medicine; 191(9):1617-1623, May 1, 2000.
XP002557887 Grier et al.; The pathophysiology of HOX genes and their role in cancer; Journal of Pathology; 205(2):154-171 Jan. 2, 2005.
XP002557888 Database Geneseq Feb. 18, 2002.
XP002557889 Database Biosis “regulation of Bmp4 signaling by phosphorylation dependent proteolysis of xom”; Apr. 2005.
XP002557890 Hong et al.; “Hom-1 inhibits tumor growth in both p53 sufficient and deficient colon cancer cells”; Gastroenterology, 134(4), Suppl. 1 p. A744 Apr. 2008.
XP002557891 Arseni et al; “The vent-like homeobox gene VENTX2 is expressed in human hematopoietic progenitor cells and promotes human myeloid development in vitro and in vivo” Blood; 110(11) part 1; pp. 383A-384A, 2007.
XP002557892 Arseni et al.; “VENTX2-A vent-like homeobox gene- is a novel candidate for a hematopoietic regulatory protein”; Experimental Hematology; 35(9), Suppl. 2 p. 45, Sep. 2007.
XP002557894 Hong et al.; “Xom interacts with and stimulates transcriptional activity of LEF1/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis” Cell Research; 17(4):345-356, Apr. 2007.

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