Treatment of cardiac dysfunction with 15-ketoprostaglandin compo

Details Treatment of cardiac dysfunction with 15-ketoprostaglandin compo Treatment of cardiac dysfunction with 15-ketoprostaglandin compo

1992-06-02

1993-10-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 3119, A61K 31557

Patent

active

052566960

ABSTRACT:
A method for treatment of a cardiac dysfunction which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of the cardiac dysfunction.

REFERENCES:
patent: 4639461 (1987-01-01), Nakane
patent: 4680288 (1987-07-01), Irmscher et al.
Medicinal Chemistry, 3rd ed. Alfred Burger, ed. Wiley-Interscience, N.Y. (1970) pp. 71-72, 74-75.
STN File Server & File CA & Chemical Abstracts, vol. 98, No. 11, abstract No. 84144J, Columbus, Ohio, US; US; H. J. Mest et al.: "Influence of 15-keto-metabolites and 13,14-dihydro-15-keto-metabolites of PGE2 and PGF2, alpha. as well as of 6-keto-PGF1.alpha. as a metabolite of PGI2 on aconitine induced cardiac arrhythmia in rats", & ACTA Biol. Med. Ger., 41(9), 819-22, 1982.
Patent Abstracts of Japan, vol. 7, No. 171 (C-178)[1316], Jul. 28th, 1983; & JP-A-59 79 973 (Ono Yakuhin Kogyo K.K.) May 13, 1983.
STN File Server & File CA & Chemical Abstracts, vol. 102, No. 1, abstract No. 1100u, Columbus, Ohio, US; P. Conzen et al.: "Hypoxic pulmonary vasoconstriction and endogenous prostaglandin (PG) and thromboxane (TX) release in anesthetized pigs", & Biomed. Biochim. Acta, 43 (8-9), 265-8, 1984.
Actor Phys. Scand., vol. 66, Oct. 3rd, 1966, pp. 509-510; E. Anggard: "The biological activities of three metabolites of prostaglandin E".

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