Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2004-10-12
2008-11-25
Krass, Frederick (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S078000, C514S570000, C514S221000, C514S681000, C514S944000
Reexamination Certificate
active
07456223
ABSTRACT:
A composition and its use for local percutaneous delivery of a drug, in particular a muscle relaxant, more particularly cyclobenzaprine present in an amount of about 1 to about 10% by weight of the composition in an organogel cream are disclosed. The composition is applied directly to the skin over accessible muscles of mastication from which it is rapidly absorbed through the skin to provide control of conditions such as bruxism and tooth clenching. The composition can also be applied to the skin overlying these muscles to control muscle hyperactivity (spasm) and/or trigger points, from other causes. The composition can be formulated to include another active agent such as a non-steroidal anti-inflammatory, for example ketoprofen.
REFERENCES:
patent: 5654337 (1997-08-01), Roentsch et al.
patent: 5837289 (1998-11-01), Grasela et al.
patent: 6164278 (2000-12-01), Nissani
patent: 2003/0125661 (2003-07-01), Yerushalmy
Krass Frederick
Roberts Lezah
Sommer Evelyn M.
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