Treatment of brain damage

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S093200

Reexamination Certificate

active

10342692

ABSTRACT:
The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit comprises administering a composition comprising pluripotent cells into the damaged brain in a region contra-lateral to that containing the site of damage. The cells are preferably conditionally immortal.

REFERENCES:
patent: 4690142 (1987-09-01), Ross et al.
patent: 5270191 (1993-12-01), McKay et al.
patent: 5690927 (1997-11-01), Major et al.
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753491 (1998-05-01), Major et al.
patent: 5753506 (1998-05-01), Johe
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 6197585 (2001-03-01), Stringer
patent: 6200806 (2001-03-01), Thomson
patent: 6399384 (2002-06-01), Jat
patent: 2002/0123143 (2002-09-01), Toma et al.
patent: 8903872 (1989-05-01), None
patent: WO 89/09816 (1989-10-01), None
patent: 9109936 (1991-07-01), None
patent: 9301275 (1993-01-01), None
patent: 9615226 (1996-05-01), None
patent: 9710329 (1996-09-01), None
patent: 9927076 (1998-11-01), None
patent: 0020560 (2000-04-01), None
Yoshida et al (Cell Transplantation, 1999, 8: 427-430).
Sumitran et al (Cell Transplantation, 1999, 8: 601-610).
Barker et al (The Journal of Neuroscience, 2000, 20(9): 3415-3424).
Armstrong et al (Neuroscience, 2001, 106(1): 201-216).
Larsson et al (Brain Research Bulletin, 1999, 49(5): 367-3760).
Larsson et al (Experimental Neurology, 2001, 172: 100-114).
Loseva et al (Brain Research, 2001, 915: 125-132).
Larsson et al (Scand. J. Immunol. 2000, 52: 249-256).
Bjorklund et al (Nature Neuroscience, 2000, 3(6): 537-544).
Sinden et al, Neuroscience, 81:3, 599-608, 1997.
Hodges et al. (1997)Pharm. Biochem. and Behaviorvol. 56, pp. 763-780.
McKay et al. (1990) “Mechanisms regulating Cell Number and Type in the Mammalian Central Nervous System” Cold Spring Harbor Symposia on Quantitative Biology, vol. 55, pp. 291-301.
McKay et al. (1993) “Immortalized Stem Cells From the Central Nervous System” C.R. Acad. Sci. Paris Sciences De La Vie, vol. 316, pp. 1452-1457.
Netto et al. (1993)Behavioral Brain Res. vol. 58, pp. 107-112.
Okabe et al. (1996) “Development of Neuronal Precursor Cells and Functional Postmitotic Neurons from Embryonic Stem Cells In Vitro” Mechanisms of Development, vol. 59, pp. 89-102.
Rashid-Doubell et al. (1994)Gene Therapyvol. 1, Suppl. 1, p. S63.
U.S. Appl. No. 09/672,606, filed Sep. 28, 2000, Sinden et al.
U.S. Appl. No. 09/760,274, filed Jan. 12, 2001, Sinden et al.
U.S. Appl. No. 09/696,569, filed Oct. 25, 2000, Price et al.
U.S. Appl. No. 09/663,537, filed Sep. 15, 2000, Jat.
Sanberg et al. (Feb. 1998) Proceedings of the 1998 Miami Biotechnology Symposium, vol. 38, pp. 139-142.
Scheffler et al. (1999)Trends in Neurosciencevol. 22, pp. 348-357.
Sinden, J.D., F. Rashid-Doubell, T.R. Kershaw, et al. (1997) “Recovery of Spatial Learning By Grafts Of A Conditionally Immortalized Hippocampal Neuroepithelial Cell Line Into The Ischaemia-Lesioned Hippocampus”Neurosciencevol. 81(3):599-608.
Synder et al. “Central nervous system cell transplantation: a novel therapy for storage diseases?”Curr. Opin. Neurol., 1996, 9:126-136.
Synder et al. “Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex”Proc Nat'l Scad. Sci. USA, 1997, 94(21):11663-11668.
Synder et al. “Multipotent neural cell lines can engraft and participate in development of mouse cerebellum”Cell, 1992, 68:33-51.
Shihabuddin et al. “Selective hippocampal lesions differentially affect the phenotypic fate of transplanted neuronal precursor cells”Experimental Neurology, 1996, 139(1) 61-72.
Cepko, C.L. “Immortalization of neural cells via retrovirus-mediated oncogene transduction”Ann. Rev. Neurosci., 1989, 12:47-65.
Whittemore, S.R. et al. “Isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord”GLIA, 1994, 10:211-226.
Major, E.O. et al. “Establishment of a line of human fetal glial cells that supports JC virus multiplication”Proc. Natl. Acad. Sci. USA, 1985, 82:1257-1261.
Wyllie, F.S. et al. “A phenotypically and karyotypically stable human thyroid epithelial line conditionally immortalized by SV40 large T antigen”Cancer Res., 1992, 52:2938-2945.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of brain damage does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of brain damage, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of brain damage will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3796371

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.