Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Aldehyde doai
Reexamination Certificate
2006-03-23
2009-08-25
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Aldehyde doai
C514S694000, C424S422000
Reexamination Certificate
active
07579381
ABSTRACT:
The present invention provides methods for treating tissue to inhibit post-implant calcification of a biological tissue. In one method of this invention, a tissue is immersed in or otherwise contacted with a pretreated glutaraldehyde solution, i.e., a heat-treated or pH-adjusted glutaraldehyde solution. The tissue may be partially fixed with glutaraldehyde prior to, after, or concurrently with the step of contacting the tissue with the pretreated gluteraldehyde. Contact with the pretreated gluteraldehyde produces free amine groups on the tissue, which are subsequently blocked by contacting the crosslinked tissue with a blocking agent. In another embodiment, a tissue is contacted with either a non-pretreated glutaraldehyde or a pH-adjusted glutaraldehyde solution for a period of time sufficient to crosslink the tissue. The crosslinked tissue is then treated with a reducing agent that reduces aldehyde and carboxylic acid groups on the fixed tissue.
REFERENCES:
patent: 2393580 (1946-01-01), Weiskopf
patent: 3002895 (1961-10-01), Freedman
patent: 3093439 (1963-06-01), Bothwell
patent: 3870789 (1975-03-01), Mikat
patent: 3927422 (1975-12-01), Sawyer
patent: 3961097 (1976-06-01), Gravlee, Jr.
patent: 3966401 (1976-06-01), Hancock et al.
patent: 4050893 (1977-09-01), Hancock et al.
patent: 4082507 (1978-04-01), Sawyer et al.
patent: 4120649 (1978-10-01), Schechter
patent: 4323358 (1982-04-01), Lentz et al.
patent: 4350492 (1982-09-01), Wright et al.
patent: 4372743 (1983-02-01), Lane
patent: 4402697 (1983-09-01), Pollock et al.
patent: 4405327 (1983-09-01), Pollock
patent: 4624822 (1986-11-01), Arru et al.
patent: 4648881 (1987-03-01), Carpentier et al.
patent: 4770665 (1988-09-01), Nashef
patent: 4786287 (1988-11-01), Nashef et al.
patent: 4800603 (1989-01-01), Jaffe
patent: 4885005 (1989-12-01), Nashef et al.
patent: 4911713 (1990-03-01), Sauvage et al.
patent: 4990131 (1991-02-01), Dardik et al.
patent: 5002566 (1991-03-01), Carpentier et al.
patent: 5068086 (1991-11-01), Sklenak et al.
patent: 5104405 (1992-04-01), Nimni
patent: 5116564 (1992-05-01), Jansen et al.
patent: 5131908 (1992-07-01), Dardik et al.
patent: 5275954 (1994-01-01), Wolfinbarger
patent: 5279612 (1994-01-01), Eberhardt
patent: 5447536 (1995-09-01), Girardot et al.
patent: 5595571 (1997-01-01), Jaffe et al.
patent: 5632778 (1997-05-01), Goldstein
patent: 5773285 (1998-06-01), Park
patent: 5792603 (1998-08-01), Dunkelman et al.
patent: 5882918 (1999-03-01), Goffe
patent: 6350732 (2002-02-01), Moore et al.
patent: 2003/0125813 (2003-07-01), Carpentier et al.
patent: 2003/0226208 (2003-12-01), Carpentier et al.
patent: 2004/0030405 (2004-02-01), Carpentier et al.
patent: WO 84/01894 (1984-05-01), None
patent: WO 95/11047 (1995-04-01), None
patent: WO 95/22361 (1995-08-01), None
patent: WO 95/34332 (1995-12-01), None
patent: WO 96/04028 (1996-02-01), None
patent: WO 96/13227 (1996-05-01), None
European search letter for Application No. 06 739 363.7-1219: Mar. 2008.
International Search Report for Application No. PCT/US2006/010540 dated Jul. 5, 2007.
Allied Fischer Scientific Product Catologue, pp. 914, 1986.
Cumberbatch Guy
Edwards Lifesciences Corporation
Henley, III Raymond J
Yadav Rajiv
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