Treatment of benign prostatic hyperplasia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

06989400

ABSTRACT:
A method for treatment or prophylaxis of benign prostatic hyperplasia by administration of lonidamine or a lonidamine analog is provided. Also provided are unit dosage forms of lonidamine or an analog, useful for such treatment and prophylaxis.

REFERENCES:
patent: 3895026 (1975-07-01), Palazzo et al.
patent: 4684627 (1987-08-01), Leveen et al.
patent: 4840939 (1989-06-01), Leveen et al.
patent: 5260327 (1993-11-01), Kim et al.
patent: 5827887 (1998-10-01), Gourvest et al.
patent: 6001865 (1999-12-01), Silvestrini et al.
patent: 6319517 (2001-11-01), Cavallo et al.
patent: 6337087 (2002-01-01), Cavallo et al.
patent: 6428968 (2002-08-01), Molnar-Kimber et al.
patent: 6482802 (2002-11-01), Hu et al.
patent: 2206198 (1997-05-01), None
patent: 54256 (1989-08-01), None
patent: WO 96/40142 (1996-12-01), None
patent: WO 97/14670 (1997-04-01), None
patent: WO 98/10781 (1998-03-01), None
patent: WO 2004/064735 (2004-08-01), None
patent: WO 2004/064736 (2004-08-01), None
Isaacs et al., Prostate, Supplement, (1989), 2, 33-50 (Abstract Only, Medline Acc. No. 90148756).
Kirby, Urology, (Nov. 1, 2000), 56 (5 Suppl. 1), 3-6 (Abstract Only, Medline Acc. No. 2001035623).
Harrison's Principles of Internal Medicine, 13thed. , vol. 2, published 1994 by McGraw-Hill, Inc. (NY), pp. 18-62-1865.
Stedman's Medical Dictionary, 25thEdition, published 1990, by Williams & Wilkins, p. 65, “analog”.
Belzacq et al., Oncogene, 2001, 7579-87, 20.
Belzacq et al., Biochimie, 2002, 167-76, 84.
Berruti et al., J. Clin. Oncol., 2002, 4150-9, 20(20).
Besner et al., Oncology, 1984, 48-52, 41(supp. 1).
Besner et al., Drug Metabolism Rev., 1997, 219-234, 29(1&2).
Bunn, J. Clin. Onc., 2002, 23-33, 20(18).
Calabresi et al., Sem. Onc., 1991, 66-72, 18(2).
Cionini, Sem. Onc., 1991, 49-52, 18(2) Suppl. 4.
Comella et al., J. Clin. Onc., 1999, 1526-34, 17(5).
Corsi et al., J. Med. Chem., 1976, 778-783, 19(6).
Costello & Franklin, Oncology, 2000, 269-282, 59.
Costello et al., J. Inorg. Biochem., 2000, 161-165, 78.
Cuna et al., Apr., Sem. Onc., 1991, 18-22, 18 (2 supp. 4).
De Lena et al., Eur. J. Can., 2001, 364-8, 37.
De Lena et al., J. Clin. Onc., 1997, 3208-13, 15(10).
Floridi et al., Arch. Biochem. Biophys., 1983, 73-83, 226(1).
Floridi et al., Can. Res., Nov., 1981, 4661-6, 41.
Gatzemeier et al., Sem. Onc., 1991, 42-8, 18(2) Suppl. 4.
Grima et al., Biol. Reprod., 2001, 1500-8, 64.
Heywood et al., Chemotherapy, 1981, 91-97, 27 (Suppl. 2).
Ianniello et al., 1996, Cancer, 63-9, 78(1).
Lobl et al., Chemotherapy, 1981, 61-76, 27 (Suppl. 2).
Mansi et al., Br. J. Cancer, 1991, 593-7, 64.
Muntzing et al., J. Med. Primatol., 1975, 245-251, 4.
Orlandi et al., Int. J. Can., 1998, 377-84, 78.
Orlandi et al., Anticancer Res., 1994, 1161-4, 14.
Pacini et al., Eur. J. Cancer, 2000, 966-75, 36.
Paggi et al., Ann. NY Acad. Sci., 1988, 358-60, 551.
Portalone et al., Tumori, 1999, 239-42, 85.
Possinger et al., Sem. Onc., 1991, 58-61, 18(2) Suppl. 4.
Price et al., Cancer Chemother. Phramacol., 1996, 129-135, 38.
Privitera et al., Radiother. Onc., 1987, 285-90, 10.
Ravagnan et al., Oncogene, 1999, 2537-46, 18.
Rosso et al., Sem. Onc., 1991, 62-5, 18(2) Suppl. 4.
Rotin et al., Int. J. Radiation Oncology Biol. Phys., 1984, 1595-8, 10.
Savini et al., Breast. Can. Res. Treat., 1992, 27-34, 24.
Scarantino et al., Sem. Onc., 1991, 28-32, 18(2) Suppl. 4.
Schiffer et al., Sem. Onc., 1991, 38-41, 18(2) Suppl. 4.
Silvestrini, Sem. Onc., 1991, 2-6, 18(2) Suppl. 4.
Segre et al., Chemotherapy, 1981, 77-84, 27 (Suppl. 2).
Teicher et al., Sem. Onc., 1991, 7-10, 18(2) Suppl. 4.
Teicher et al., Eur. J. Cancer, 1994, 1411-3, 30A(10).
Vieira et al., Cell Death and Differentiation, 2000, 1146-1154, 7.
Zaniboni et al., Tumori, 1995, 435-7, 81.
Isaacs et al., “Etiology and disease process of benign prostatic hyperplasia”Prostate Suppl., 2:33-50 (1989).
Hudson et al., “Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells”Lab Invest., 80:1243-1250 (2000).
Collins et al., “Benign prostatic stromal cells are regualted by basic fibroblast growth factor and transforming growth factor-beta 1”J Endocrinol., 151:315-322 (1996).
Giri et al., “Interleukin-8 is a parascrine inducer of fibroblast growth factor 2, a stromal and epithelial growth factor in benign prostatic hyperplasia”Am. J Pathol., 159:139-147 (2001).
Castro et al., “Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia”Prostate, 60:153-159 (2004).
Boccardo et al., “Phase II study with Ionidamine in the treatment of hormone-refractory prostatic cancer patients”Tumori, 78:137-139 (1992).
Dudak et al., “Enhancement of radiation response of prostatic carcinoma by Ionidamine”Anticancer Res., 16:3665-3671 (1996).
Bloch et al., “Enhancement of hyperthermic toxicity by Ionidamine in the Dunning R3327G rat prostatic adenocarcinoma”Prostate, 24:131-138 (1994).
Benz et al., “Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123,”J Clin Invest. 79:517-523. (1987).
Eri et al., “Effects on the endocrine system of long-term treatment with the luteinizing hormone-releasing hormone agonist leuprolide in patients with benign prostatic hyperplasia”Scandinavian Journal of Clinical and Laboratory Investigation, 56: 319-325 (1996).
International Search Report and Written Opinion for PCT/US2004/001141 (WO 2004/064735) (Sep. 22, 2004).
International Search Report and Written Opinion for PCT/US2004/001146 (WO 2004/064736) (Mar. 1, 2005).
Lobl, 1979, “1-(2,4-Dicholorobenzyl)-1H-Indazole-3Carboxylic Acid (DICA), and Exfoliative Antispermatogenic Agent in the Rat”Arch Andrology2:353-63.
Shidaifat et al, 1997, “Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle”Anticancer Res. 17:1003-9.
Chang, 1997, “Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells”Biochem Biophys Res Commun. 231:383-8.

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