Treatment of bacterial dysentery

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 25, 514 54, A61K 3170, A61K 31175

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active

058497145

ABSTRACT:
Disclosed are methods for the neutralization of shiga-like toxins (SLT) associated with enteric E. coli infection which methods inhibit progression of this infection into hemolytic uremic syndrome (HUS).

REFERENCES:
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 4362720 (1982-12-01), Lemieux et al.
patent: 5079353 (1992-01-01), Ratcliffe et al.
patent: 5484773 (1996-01-01), Heerze et al.
patent: 5620858 (1997-04-01), Armstrong et al.
patent: 5679653 (1997-10-01), Armstrong et al.
Chemical Abstracts (Lund et al) EP 35482 AZ (Abstract), 1981.
Armstrong, Glen D., et al., "Investigation of Shiga-Like Toxin Binding to Chemically Synthesized Oligosaccharide Sequences", J. Infect. Dis., 164(6):1160-1167 (1991).
Armstrong, Glen D., et al, "A Phase I Study of Chemically Synthesized Verotoxin (Shiga-Like Toxin) Pk-Trisaccharide Receptors Attached to Chromosorb for Preventing Hemolytic-Uremic Syndrome", J. Infect. Dis., 171(4):1042-1045 (1995).
Abbas, S.Z., et al., "Tumor-Associated Oligosaccharides I: Synthesis of Sialyl-Lewis.sup.a Antigenic Determinant", Sialic Acids, Proc. Japan-German Symp., Berlin:22-23 (1988).
Altman, D.G., et al., Practical Statistics for Med. Res., 1st Ed., New York, Chapman and Hall:179-228 (1991).
Amvam-Zollo, P.H., et al., "Streptococcus pneumoniae Type XIV Polysaccharide: Synthesis of a Repeating Branched Tetrasaccharide with Dioxa-Type Spacer-Arms", Carbohy. Res., 150:199-212 (1986).
Armstrong, G.D., et al., "Maintenance of Biological Activity of Pertussis Toxin Radioiodinated While Bound to Fetuin-Agarose", Infect. Immun., 55(5):1294-1299 (1987).
Armstrong, G.D., et al., "Investigation of Shiga-Like Toxin Binding to Chemically Synthesized Oligosaccharide Sequences", J. Infect. Dis., 164:1160-1167 (1991).
Boyd, B., et al., "Verotoxin Receptor Glycolipid in Human Renal Tissue", Nephron, 51:207-210 (1989).
Calderwood, S.B., et al., "Nucleotide Sequence of the Shige-Like Toxin Genes of Eschericia coli", Proc. Natl. Acad. Sci. (USA), 84:4364-4368 (1987).
Chernyak, A.Y., et al., "A New Type of Carbohydrate-Containing Synthetic Antigen: Synthesis of Carbohydrate-Containing Polyacrylamide Copolymers Having the Specificity of O:3 and O:4 Factors of Salmonella", Carbohy. Res., 128:269-282 (1984).
Cimolai, N., et al., J. Pediatr., 117:676 (1990).
Cohen, A., et al., "Roles of Globotriosyl- and Galabiosylceramide in Verotoxin Binding and High Affinity Interferon Receptor", J. Biol. Chem., 262(35):17088-17091 (1987).
Cox, D.D., et al., "A New Synthesis of 4-O-.alpha.-D-Galactopyranosyl-D-Galactopyranose", Carbohy. Res., 62:245-252 (1978).
Dahmen, J., et al., "2-Bromoethyl Glycosides: Applications in the Synthesis of Spacer-Arm Glycosides", Carbohy. Res., 118:292-301 (1983).
Dahmen, J., et al., "Synthesis of Spacer-Arm., Lipid, and Ethyl Glycosides of the Trisaccharide Portion the Blood-Group P.sup.k Antigen: Preparation of Neoglycoproteins", Carbohy. Res., 127:15-25 (1984).
DeGrandis, S., et al., "Globotetraosylceramide is Recognized by the Pig Edema Disease Toxin", J. Biol. Chem., 264(21):12520-12525 (1989).
Ekborg, G., et al., "Synthesis of Three Disaccharides for the Preparation of Immunogens Bearing Immunodeterminants Known to Occur on Glycoproteins", Carbohy. Res., 110:55-67 (1982).
Ferandez-Santana, V., et al., "Glycosides of Monoallyl Diethylene Glycol. A New Type of Spacer Group for Synthetic Oligosaccarides", J. Carbohy. 1Chem., 8(3):531-537 (1989).
Fugedi, P., et al., "Thioglycosides as Glycosylating Agents in Oligosaccharide Synthesis", Glycoconjugate J., 4:97-108 (1987).
Gannon, et al., "Molecular Cloning and Nucleotide Sequence of Another Variant of the Escherichia coli Shiga-Like Toxin II Family", J. Genl. Microbiol., 136:1125-1135 (1990).
Garegg, P.J., et al., "A Synthesis of 8-Methoxycarbonyloct-1-YL .omicron.-.alpha.-D-Galactopyranosyl-(1.fwdarw.3)-O-.beta.-D-Galactopyrano syl-(1-.fwdarw.4)-2-Acetamido-2-Deoxy-.beta.-D-Glucopyranoside", Carbohy. Res., 136:207-213 (1985).
Garegg, P.J., et al., "Synthesis of 6- and 6'-Deoxy Derivatives of Methyl 4-.omicron.-.alpha.-D-Galctopyranosyl-.beta.-D-Galactopyranoside for Studies of Inhibition of Pyelonephritogenic Fimbriated E. Coli Adhesion to Urinary Epithelium-Cell Surfaces", Carbohy. Res., 137:270-275 (1985).
Head, S., et al., "Modification of the Glycolipid-Binding Specificity of Vero Cytotoxin by Polymyxin B and Other Cyclic Amphipathic Peptides", Infect. Immun., 58(6):1532-1537 (1990).
Head, S.C., et al., "Purification and Characterization of Verocytotoxin 2", FEMS Microbiol. Lett., 51:211-216 (1988).
Ito, et al., "Cloning and Nucleotide Sequencing of Vero Toxin 2 Variant Genes from Escherichia Coli 091:H21 Isolated from a Patient with the Hemolytic Uremic Syndrome", Microbial Pathog., 8:47-60 (1990).
Jacewicz, M., et al., "Pathogenesis of Shigella Diarrhea XI. Isolation of a Shigella Toxin-Binding Glycolipid from Rabbit Jejunum and HeLa Cells and its Identification as Globotriaosylceramide", J. Exp. Med., 163:1391-1404 (1986).
Jackson, M.P., et al., "Nucleotide Sequence Analysis of the Structural Genes for Shiga-Like Toxin I Encoded by Bacteriophage 933J from Escherichia Coli", Microbial Pathog., 2:147-153 (1987).
Jacquinet, J.C., et al., "Synthesis of Blood-Group Substances. Part 11. Synthesis of the Trisaccharide .omicron.-.alpha.-D-Galactopyranosyl-(1.fwdarw.3)-.omicron..beta.-D-Galact opyranosyl-(1.fwdarw.4)-2-Acetamido-2-Deoxy-D-glucopyranose", J.C.S. Perkin, I:326-330 (1981).
Kameyama, A., et al., "Total Synthesis of Sialyl Lewis X", Carbohy. Res., 209:c1-c4 (1991).
Karmali, M.A., et al., "Sensitive Method for Detecting Low Numbers of Verotoxin-Producing Escherichia Coli in Mixed Cultures by Use of Colony Sweeps and Polymyxin Extraction of Verotoxin", J. Clin. Microbiol., 22(4):614-619 (1985).
Koike, K., et al., "Total Synthesis of Globotriaosyl-E and Z-Ceramides and Isoglobotriaosyl-E-Ceramide", Carbohy. Res., 163:189-208 (1987).
Lee, R.T., et al., "Synthesis of 3-(2-Aminoethylthio)Propyl Glycosides", Carbohy. Res., 37:193-201 (1974).
Lemieux, R.U., et al., "The Properties of a `Synthetic` Antigen Related to the Human Blood-Group Lewis.sup.2 ", J. Amn. Chem. Soc., 97(14):4076-4083 (1975).
Lingwood, C.A., et al., "Glycolipid Binding of Purified and Recombinant Escherichia Coli Produced Verotoxin in Vitro", J. Biolog. Chem., 262(18):8834-8839 (1987).
Lindberg, A.A., et al., "Identification of the Carbohydrate Receptor for Shiga Toxin Produced by Shigella dysenteriae Type 1", J. Biolog. Chem., 262(4):1779-1785 (1987).
Okamoto, K., et al., "Glycosidation of Sialic Acid", Tetrahedron, 47:5853-5857 (1990).
Oku, et al., Microbial Pathog., 6:113-122 (1989).
Paulsen, H., "Advanced in Selective Chemical Syntheses of Complex Oligosaccharides", Angew. Chem. Int. Ed. Eng., 21(3):155-173 (1982).
Paulsen, H., et al., "Synthese Von Oligosaccharid-Determinanten Mit Amid-Spacer Vom Typ Des T-Antigens", Carbohy. Res., 104:195-219 (1982).
Rana, S.S., et al., "Synthesis of Phenyl 2-Acetamido-2-Deoxy-3-.omicron.-.alpha.-L-Fucopyranosyl-.beta.-D-Glucopyra noside and Related Compounds", Carbohy. Res., 91:149-157 (1981).
Robson, W.L.M., et al., "Influence of Antidiarrheal and Antimicrobial Medications on the Hemorrhagic Colitis Associated with Hemolytic-Uremic Syndrome", J. Pediatr., 117:675-676 (1990).
Samuel, J.E., et al., "Comparison of the Glycolipid Receptor Specificities of Shiga-Like Toxin Type II and Shiga-Like Toxin Type II Variants", Infect. Immun., 58(3):611-618 (1990).
Schaubach, R., et al., "Tumor-Associated Antigen Synthesis: Synthesis of the Gal-.alpha.-(1.fwdarw.3)-Gal-.beta.-(1.fwdarw.4)-GlcNAc Epitope. A Specific Determinant for Metastatic Progression?", Liebigs Ann. Chem., 607-614 (1991).
Schmidt, R.R., "New Methods for the Synthesis of Glycosides and Oligosaccarhides--Are There Alternatives to the Koenigs-Knorr Method?", Angew. Chem. Int. Ed. Eng., 25:212-235 (1986).
Schmitt, C.K., et al., "Two Copies of Shiga-Like Toxin II-Related Genes Common in Enterohemorrhagic Escherichia coli Strains Are Responsible for the Antigenic Heterogeneity of the 0157:H S

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