Treatment of autoimmune diseases with IL-2 receptor-specific cyt

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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424 852, 4241831, 4241821, 4241441, 4241731, A61K 3820, A61K 39395, A61K 4500

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active

056076754

ABSTRACT:
A method of treating a mammal suffering from an autoimmune disease state is provided. The method comprises administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocytes associated with the disease state, whereby the lymphocytes undergoing the proliferative burst are selectively killed.

REFERENCES:
patent: 4359457 (1982-11-01), Neville et al.
patent: 4388309 (1983-06-01), Fabricius
patent: 4440747 (1984-04-01), Neville
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4489710 (1984-12-01), Spitler
patent: 4520226 (1985-05-01), Neville et al.
patent: 4545985 (1985-10-01), Pastan
patent: 4550086 (1985-11-01), Reinherz et al.
patent: 4675382 (1987-06-01), Murphy
patent: 4677061 (1987-06-01), Rose et al.
patent: 4908433 (1990-03-01), Mertelsmann
patent: 4946674 (1990-08-01), von Eichborn et al.
patent: 5011684 (1991-04-01), Strom
patent: 5336489 (1994-08-01), Strom
patent: 5510105 (1996-04-01), Strom
Takahashi et al. (1983) The Lancet pp. 1155-1158.
Williams et al. (1984) J. Immunol. 132(5), 2330.
Kirkman et al., (1983) Transplantation 36(6), 620.
Zubler, et al. (1984) J. Exp. Med. 160 (4), 1170.
Leonard, et al. (1982) Nature 300, 267.
FitzGerald, et al. (1984) J. Clin. Invest. 74, 966.
Depper, et al. (1983) J. Immunol. 131 (2), 690.
Cotner, et al. (1983) Journal of Experimental Medicine 157 461-472.
Knox, R., "Researchers find new way to stop organ rejection," Boston Globe, May 5, 1985, p. 20.
Kelley, V. E., et al., J. Immunol. 140:59-61 (1988).
Lorberboum-Galski, H. et al., Proc. Natl. Acad. Sci. USA 86:1008-12 (1989).
Kirkman et al., Transplantation 40(6):719-22 (1985).
Fahey, et al., Annals of Internal Med. 106:257-74 (1987).
Case, et al., PNSA USA 86:287-91 (1989).
Decker, et al., Ann. Int. Med. 101:810-24 (1984).
Powers, et al., Ann. Rev. Med. 36:533-44 (1985).
Prud'homme, et al., Diabetes 33:801-03 (1984).
Rossini, et al., Diabetes 33:543-47 91984).
Hofman et al., J. Immunol. 136:3239-45 (1986).
Fleischer et al., J. Neuroimmunol. 7:151-62 (1984).
Kronke et al., Blood 65(6):1416-1421 (1985).
Shimizu et al., Cell Structure and Function, 9, 1984, pp. 203-212.
Vallera et al., Science 222:512-515 (1983).
Strong et al., Blood 66(3):627-635 (1985).
Waldmann, "The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes," Science 232:727-732 (1986).
Olsnes, et al., Pharmacol. Ther. 15:355-381 (1981).
Sewell, et al., Arthrit. & Rheum. 36(9):1223-1233 (1993).
Gottlieb, et al., (Nature Medicine) 1(5):1442-1447 (1995).
Stenmark, et al., J. Cell Biol. 113(5):1025-1032 (1991).
Kirkman, et al., J. Exp. Med. 162(1):358-362 (1985).
Gaulton, et al., Clin. Immunol. Immunopathol. 36(1):18-29 (1985).
Federation Proceedings, vol. 44(4), 1681, Abstract No. 7430, Mar., 1985.
Clinical Research, vol. 33(2), 561A, Apr., 1985.
Federation Proceedings, 44(6), 1881, Abstract No. 8589, Mar. 1985.
Bellamy, et al., Clin. Exp. Immunol. 61(2):248-256, Aug. 1985.
Howard, et al., Transplantation Proceedings, 13(1):473-474 (1981).
Uchiyama, et al., J. Immunol. 126(4):1393-1397 (1981).
Cantrell, et al., J. Exp. Med. 158:1895-1911 (1983).
Heidecke, et al., J. Immunol. 133(2):582-588 (1984).
Reem, et al., Science 225:429-430 (1984).
Cantrell, et al., Science 224:1312-1316 (1984).
Najarian, et al., Ann. Surg. 184:352-368 (1976).
Waldmann, Annu. Rev. Biochem. 58:875-911 (1989).
Brostoff et al., J. Immunol. 133(4):1938-1942 (1984).
Waldor et al., Science 227:415-417 (1985).
Biosis Abs. No. 29034133.

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