Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1996-12-23
1999-03-30
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241401, 4241431, 604 5, 604 6, 53038822, 53038823, 5303892, 5303911, A61K 39395, A61K 3900
Patent
active
058885110
ABSTRACT:
The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor, HLA class II antigens, IgE, and other pathological factors and/or their receptors, as well as neutralizing, removing or inhibiting autoantibodies, including antibodies to target cells, CD4 cells and DNA. Treatment comprises administration of an autoimmune inhibitor, or extracorporeal exposure of the patient's fluid to an immunosorbent comprising an autoimmune inhibitor, followed by return of the treated fluid to the patient, or it comprises a combined therapy involving extracorporeal immunosorption in conjunction with the administration of an autoimmune inhibitor.
REFERENCES:
patent: 4362155 (1982-12-01), Skurkovich
patent: 4605394 (1986-08-01), Skurkovich
patent: 4824432 (1989-04-01), Skurkovich et al.
van Joost, et al., J. Am. Acad. Dermatol., vol. 27 (6 Pt 1), pp. 922-928, Dec. 92.
Aderka et al., "Correlation between Serum Levels of Soluble Tumor Necrosis Factor Receptor and Disease Activity in Systemic Lupus Erythematosus," Arthritis Rheum. 36(8):1111-1120 (1993).
Altomonte et al., "Serum Levels of Interleukin-1b, Tumor Necrosis Factor-a and Interleukin-2 in Rheumatoid Arthritis, Correlation with Disease Activity," Clin. Rheum. 11(2):202-205 (1992).
Bevan et al., "Interferon Induced Parotitis and Epididymitis," Lancet 2:561 (1985).
Biglino et al., "Spontaneous Release of Interferon as a Predictor of Clinical Evolution in HIV-Positive Subjects," Infection 19(1):11/7-11/17 (1991).
Billard et al., "IFN.alpha. in Vivo Enhances Tumor Necrosis Factor Receptor Levels on Hairy Cells," J. Immunol. 145:1713-1718 (Sep. 1990).
Brahn et al., "Effects of Tumor Necrosis Factor Alpha (TNF.alpha.) on Collagen Arthritis," Lymphokine and Cytokine Res. 11(5):253-256 (1992).
Brennan et al., "TNF.alpha. -- A Pivotal Role in Rheumatoid Arthritis," Brit. J. Rheum. 31(5):293-8 (1992).
Brod et al., "Interferon-.beta..sub.1b Treatment Deceases Tumor Necrosis Factor-.alpha. and Increases Interleukin-6 Production in Multiple Sclerosis," Neurology 46: 1633-1638 (Jun. 1996).
Burton, "Human Monoclonal Antibodies, Achievement and Potential," Hospital Practice 667-74 (Aug. 1992).
Carpenter et al., "The Pathogenesis of Autoimmunity in New Zealand Mice," Lab Invest. 23:628-634 (1970).
Chazerain et al., "Rheumatoid Arthritis-like Disease after Alpha-Interferon Therapy," Ann. Intern. Med. 116:427 (Mar. 1992).
Conlon et al., "Exacerbation of Symptoms of Autoimmune Disease in Patients Receiving Alpha-Interferon Therapy," Cancer 65:2237-2242 (1990).
Danis et al., "Circulating Cytokine Levels in Patients with Rheumatoid Arthritis: Results of a Double Blind Trial with Sulphasalizine," Ann. Rheum. Disease 51(8):946-950 (1992).
Deleuran et al., "Localization of Tumor Necrosis Factor Receptors in the Synovial Tissue and Cartilage-Pannus Junction in Patients with Rheumatoid Arthritis," Arthritis Rheum. 35(10):1170-78 (1992).
DeStafano et al., "Acid-Labile Human Leukocyte Interferon in Homosexual Men with Karposi's Sarcoma and Lymphadenopathy," J. Infec. Disease 146:451-455 (1982).
Dorsett et al., "Anti-Lymphocyte Antibodies in Patients with the Acquired Immune Deficiency Syndrome," Am. J. Med. 78:621-626 (1985).
Elliott et. al., Treatment of Rheumatoid Arthritis with Chimeric Monoclonal Antibodies to TNF-.alpha.: Safety, Clinical Efficacy and Control of the Acute Phase Response, J. Cellular Biochemistry, Suppl. 17B:145 (1993).
Elliott et al., "Repeated Therapy with Monoclonal Antibody to Tumor Necrosis Factor .alpha. (cA2) in Patients with Rheumatoid Arthritis," Lancet 344:1125-1127 (1994).
Engleman et al., Treatment of NZB/NZW F.sub.1 Hybrid Mice with Mycobacterium bovis Strain BCG or Type II Interferon Preparations Accelarates Autoimmune Disease," Arthr. Rheum. 24:1396-1402 (1981).
Fattovich et al., "Autoantibodies during Interferon-.alpha. Therapy for Chronic Hepatitis B," Br. J. Med. Virol. 34:132-135 (1991).
Feldman, et al., "Interferons and Autoimmunity," In IFN 9, Academic Press, p. 75 (1987).
Foulis et al., "Immunoreactive .alpha.-Interferon in Insulin-Secreting .beta. Cells in Type I Diabetes Mellitus," Lancet 2:1423-1427 (1987).
Gendelman et al., "Induction of IFN.alpha. in Peripheral Blood Mononuclear Cells by HIV-Infected Monocytes," J. Immunol. 148:422-429 (1992).
Graninger et al., "Induction of Systemic Lupus erythematosus by Interferon-.gamma. in a Patient with Rheumatoid Arthritis," J. Rheumatol. 18:1621-1622 (1981).
Gringeri et al., "Anti-Alpha Interferon Immunization Safety and Immunogenicity in Asymptomatic HIV Positive Patients at High Risk of Disease Progression," Cell. Mol. Biol. 41(3):381-387 (1995).
Gringeri et al., "Absence of Clinical, Virological, and Immunological Signs of Progression in HIV-1-Infected Patients Receiving Active Anti-Interferon-.alpha. Immunization: A 30-Month Follow-Up Report," J. Acquir. Immun. Defic. Syndr. 13:55-67 (1996).
Heremans et al., "Interferon Treatment of NZB Mice Accelerated Progression of Autoimmune Disease," Infect. Immun. 21:925-930 (1978).
Hess et al., "Tumor Necrosis factor and Interferon as Prognostic Markers in Human Immunodeficiency Virus (HIV) Infection," Infection 19, Suppl. 2:S93-97 (1991).
Hirano et al., "Interleukin-6 and Its Relation to Inflammation and Disease," Clin. Immunol. 62:S60-S65 (1992).
Holt et al., "Cytokine Inter-Relationships and the Association with Disease Activity in Arthritis," Brit. J. Rheum. 21(11):725-733 (1992).
Hooks et al., "Immune Interferon in the Circulation of Patients with Autoimmune Disease," N. Engl. J. Med. 301:5-8 (1979).
Johnson et al., "The Role of Antimyosin Antibodies in Acute Myocardial Infarction," Sem. Nuc. Med. 19:238 (1989).
Larrey et al., "Exacerbation of Multiple Sclerosis after the Administration of Recombinant Human Interferon Alfa," JAMA 261:2065 (1989).
Lau et al., "Regulation of Tumor Necrosis Factor Receptor Expression of Acid-Labile Interferon-.alpha. from AIDS Sera," AIDS Research and Human Retroviruses 7:545-552 (1991).
Leinonen et al., "Circulating Immune Complexes Containing Chlamydial Lipopolysaccharide in Acute Myocardial Infarction," Microbiol. Path. 9:67-73 (1990).
Libikova et al., "Orbiviruses of the Kemerovo Complex and Neurological Disease," Med. Microbiol. Immun. 166:355-263 (1978).
Libikova et al., "Assay of Interferon and Viral Antibodies in the Cerebrospinal Fluid in Clinical Neurology and Psychiatry," Acta. Biol. Med. Germ. 38:879-893 (1979).
Link et al., "Increased Transforming Growth Factor-.beta., Interleukin-4, and Interferon-.gamma. in Multiple Sclerosis," Ann. Neurol. 36:379-386 (1994).
Livden et al. "In Situ Localization of Interferons in Psoriatic Lesions," Arch. Dermatol. Res. 281(6):392-397 (1989).
Machold et al., "Interferon-.gamma. Induced Exacerbation of Systemic Lupus Erythematosus," J. Rheumat. 17(6):831-832 (1990).
Matsuyama et al., "Cytocidal Effect of Tumor Necrosis Factor on Cells Chronically Infected with Human Immunodeficiency Virus (HIV): Enhancement of HIV Replication," Proc. Natl. Acad. Sci. USA 86:2365-2509 (1989).
Mauritz et al., "Treatment with Gamma-Interferon Trigger the Onset of Collagen Arthritis in Mice," Arthritis & Rheumatism 31:1297-1304 (1988).
Meijer et al., "Profiles of Cytokines (TNF.alpha. and IL-6) and Acute Phase Proteins (CRP and .alpha.1AG) Related to the Disease Course in Patients with Systemic Lupus Erythematosus," Lupus 2:359-365 (1993).
Montalban et al., "Antiphospholipid Antibodies in Cerebral Ischemia," Stroke 22:750-753 (1991).
Paniteh et al., "Exacerbations of Multiple Sclerosis in Patients Treated with Gamma Interferon," Lancet 1:893-894 (1987).
Preble et al., "Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon," Science 216:429-431 (1982).
Preble et al., "Serum Interferon in Patients with Psychosis," Am. J. Psychiatry 142(10):1184-1186 (1985).
Quesada et al., "Psoriasis and Alpha-Interferon," Lancet 2:1466-1468 (1986).
Quesada et al., "Clinical Toxicity of Interferons in Cancer Patients: A
Skurkovich Boris
Skurkovich Simon V.
Advanced Biotherapy Concepts, Inc.
Scheiner Toni R.
LandOfFree
Treatment of autoimmune diseases, including AIDS does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of autoimmune diseases, including AIDS, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of autoimmune diseases, including AIDS will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1211827