Treatment of autoimmune disease using tolerization in combinatio

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

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424810, 514 2, 514 3, 514 4, 514 21, 514826, 514866, 514885, 514903, 514253, A61K 3900, A61K 3817, A61K 3828, A61K 3800

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active

059355778

ABSTRACT:
A combination of a mucosally administrable bystander antigen and an orally, enterally, or parenterally administrable methotrexate is employed to make a pharmaceutical formulation and to treat or prevent autoimmune disease. The amounts of bystander antigen and methotrexate are effective in combination to suppress autoimmune response associated with the autoimmune disease

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Trentham, D.E. et al. Science 261:1727-1730, Sep. 1993.
Barnett, M.L. et al. Arthritis & Rheumatism 39(4):623-628, Apr. 1996.

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