Treatment of atherosclerosis with angiotensin II receptor blocki

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514460, 514547, A61K 3141, A61K 3135, A61K 31235

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active

056631871

ABSTRACT:
A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II antagonist. This method of treatment can be used in conjunction with the treatment of hypertension. Substituted imidazoles such as ##STR1## are useful as angiotensin II receptor antagonists for this method of treatment. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor and an angiotensin converting enzyme inhibitor. Also within the scope of this invention are pharmaceutical compositions for this method of use.

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patent: 5218125 (1993-06-01), Chen et al.
patent: 5225428 (1993-07-01), Kramer et al.
Mol et al., "Effects of Synvinolin (MK-733) on Plasma Lipids in Familial Hypercholesterolemia,"The Lancet, Oct. 25, 1986, vol. II, pp. 936-939.
The Merck Manual, 1987, pp. 386-389.

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