Treatment of asbestos and silicates to reduce their toxicity

Details Treatment of asbestos and silicates to reduce their toxicity Treatment of asbestos and silicates to reduce their toxicity

1990-09-13

1992-10-13

Waddell, Frederick E.

Chemistry of inorganic compounds

Silicon or compound thereof

Oxygen containing

423331, 514121, 514566, A61K 3166, A61K 31195, C01B 3320, C01B 3324

Patent

active

051549034

ABSTRACT:
This invention pertains to an improved method of inhibiting peroxide-reduction catalytic activity and concomitant toxicity of asbestos and nonasbestos iron-containing silicates. These undesirable reactions can be substantially reduced or essentially eliminated by contacting these potentially harmful materials with an aqueous solution comprising a non-mutagenic non-toxic iron chelating agent, such as phytic acid, diethylenetriamine pentaacetic acid (DTPA) or derivatives of these.

REFERENCES:
patent: 4474742 (1984-10-01), Graceffa et al.
Rasmussen, L. et al., In Vitro Cell Dev Biol 22(4):177-179 (Apr. 1986).
Vullo, C. et al., Haematologica 74 (5 Suppl): 241-25) (Oct. 1989).
Waxman, H. S. et al., Prog Hematol 6:338-373 (1969).
Winston, G. W. et al., Arch Biochem Biophys 232(1):378-390 (Jul. 1984).
Henriksson, R. et al., Cancer Lett. 43(3):179-183 (Dec. 15, 1988).
Morehouse, L. A. et al., Arch Biochem Biophys 232(1):366-377 (Jul. 1984).
Pippard, M. J. et al., Scand J Haematol 36(5):466-472 (May 1986).
Pitt, C. G. et al., "Development of Iron Chelators for Clinical Use" Nih, Bethesda (1976).
Timbrell, V., "Characteristics of the International Union Against Cancer Standard Reference Samples of Asbestos", pp. 2-10 (1969).
De Waele, J. K. and F. C. Adams, Scanning Microscopy 2:209-228 (1988).
Harrington, J. S., Annals New York Academy of Sciences, 132:31-47 (1965).
Pooley, F. D., Seminars in Oncology, 8:243-249 (1981).
Weitzman, S. A. and P. Graceffa, Arch. Biochem. Biophys. 228:373-376 (1984).
Graf, E. et al., J. Biol. Chem. 259:3620-3624 (1984).
Zalma, R. et al., Can. J. Chem. 65:2338-2341 (1988).
Kennedy, T. P. et al., Arch. Biochem. Biophys. 269:359-364 (1989).
Graf, E., JAOCS 60:1861-1867 (1983).
Graf, E. and J. W. Eaton, Cancer 56:717-718 (1985).
Gulumian, M. and J. A. Van Wyk Chem. Biol. Interactions 62:89-97 (1987).

Affiliated with

Also associated with

Rating

Treatment of asbestos and silicates to reduce their toxicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of asbestos and silicates to reduce their toxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of asbestos and silicates to reduce their toxicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1298902