Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2007-07-31
2007-07-31
Saucier, Sandra E. (Department: 1651)
Surgery
Diagnostic testing
Cardiovascular
C435S007710, C435S194000, C424S094500
Reexamination Certificate
active
10353759
ABSTRACT:
This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions comprising a calcium/calmodulin-dependent protein kinase inhibitor and a pharmaceutically acceptable carrier and methods for identifying agents useful for the treatment of arrhythmias.
REFERENCES:
Sumi et al. (1991). “The newly synthesized selective Ca(2+)/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells,” Biochem. Biophys. Res. Comm., vol. 181, pp. 968-975.
BioTech Life Science Dictionary entry for “in vivo.”
P. Meyer et al (1995). “Novel and uncommon isoforms of the calcium sensing enzyme calcium/calmodulin dependent protein kinase II in heart tissue,” Basic Research in Cardiology vol. 90, pp. 372-379.
J. Wei et al (1996). “Phosphorylation and inhibition of type III adenyl cyclase by calmodulin-dependent protein kinase II in vivo,” The Journal of Biological Chemistry vol. 271, pp. 24231-24235.
BioTech Life Science Dictionary entry for “in vivo.”, 2005.
Wu, Yuejin, et al.; Calmodulin Kinase II and Arrhythmiss in a Mouse Model of Cardiac Hypertrophy,Circulation106: 1288-1293.
Anderson Mark
Braun Andrew P.
Schulman Howard
Sung Ruey J.
Barnhart Lora E
Saucier Sandra E.
The Board of Trustees of the Leland Stanford Jr. University
Townsend & Townsend & Crew LLP
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