Treatment of arrhythmia by administration of Ap.sub.4 A

Details Treatment of arrhythmia by administration of Ap.sub.4 A Treatment of arrhythmia by administration of Ap.sub.4 A

1990-11-20

1993-06-15

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2622, A61K 3170

Patent

active

052198413

ABSTRACT:
The present invention relates to a pharmaceutical composition for treating a heart disease which comprises a therapeutically effective amount of diadenosine 5',5'"-P.sup.1, P.sup.4 -tetraphosphate as an active ingredient in admixture with a pharmaceutically acceptable carrier or diluent. The pharmaceutical composition is particularly characterized by having antiarrhythmic and coronary vasodilative activities. The present invention also relates to a method for treating a subject having a heart disease or particularly arrhythmia, which comprises administering to the subject an effective amount of the pharmaceutical composition.

REFERENCES:
patent: 3321463 (1967-05-01), Moffatt
Busse et al., "Vasomotor Activity of Diadenosine Triphosphate and Diadenosine Tetraphosphate in Isolated Arteries," Am. J. Physiol., 254(5), H828-H832 (1988).
Nees, "Coronary Flow Increases Induced by Adenosine and Adenine Nucleotides Are Mediated by the Coronoray Endothelium: A New Principle of the Regulation of Coronary Flow," European Heart J., 10, Supplement F, 28-35 (1989).
"Martindale, The Extra Pharmacopoeia, 29th Ed.," Reynolds et al. eds., The Pharmaceutical Press, London, 1989, at p. 1492, see entires for AMP (#9201-m) and ATP (#9203-v).
Luthje, J., Klinisch Wochen-schrift 67:317-327 (1989).
Luthje et al., Biochem. Biophys. Res. Comm, 118(3), 704-709 (1984).
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Harrison et al., FEBS Letters, 54(1), 57-60 (1975).
Elmaleh et al., Proc. Natl. Acad. Sci. USA, 81, 918-921 (1984).
"Metabolism of Diadenosine Tetraphosphate (Ap.sub.4 A)," Conference Abstracts published in Hoppe-Seyler's Z. Physiol. Chem., 365, S597-611 (1984).
Guranowski et al., Biochemistry, 26, 3425-3429 (1987).
Feldhaus et al., Chem. Abstr., 83: 159,849u (1975); see also Eur. J. Biochem., 57(1), 197-204 (1975).
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