Treatment of anxiety in benzodiazepine-withdrawn patients

Details Treatment of anxiety in benzodiazepine-withdrawn patients Treatment of anxiety in benzodiazepine-withdrawn patients

1993-06-01

1994-01-11

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, A61K 31495

Patent

active

052781640

ABSTRACT:
A method of treatment of anxiety in benzodiazepine-withdrawn patients by administering BMY 14802 or, preferably, the R-(+)- enantiomer to a patient in need of such treatment.

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McMillen, et al.; Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs; 40:885-887 (1988) (3/1).
Schweizer, et al.; Failure of Buspirone to Manage Benzodiazepine Withdrawal, 143:12, 1590-1592 (1986) (3/14).
Goudie, et al.; Evaluation ofthe Dependence potential of the selective 5-H1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal 103:529-537 (1991) (3/20).
Costall, et al.; The Effects of Ondansetron (GR38032F) in Rats and Mice Treated Subchronically with Diazepam; 34: 769-778 (1989) (3/28).
McMillen et al., Soc. Neurosci. Abstr. vol. 13, No. 1, (1987) p. 452.
Vandermaelen, et al., European Journal of Pharmacology vol. 179, No. 3, (1990) 357-366.
File, et al., Psychopharmacology, vol. 105, No. 4, (12/91) 578-582.

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