Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to era

Details Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to era Treatment of animals with 2,6-bis(2-hydroxybenzyl)phenols to era

1977-07-05

1979-08-07

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424304, 424307, 424308, 424309, 424317, 424341, 424346, 424348, A61K 31055, A61K 3105, A61K 31275

Patent

active

041638018

ABSTRACT:
A process for killing internal parasites of warm blooded animals which process comprises treating the infected animal with an effective amount of a composition comprising as active ingredient a compound of the general formula I: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, lower alkyl, lower alkenyl, lower alkanoyl, lower alkenoyl, aroyl or CH.sub.2 COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl; B, C and D, which may be the same or different, are halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is hydroxy, lower alkoxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7, which may be the same or different, are hydrogen or lower alkyl; A, E, X, Y and Z, which may be the same or different, are hydrogen, halogen, optionally substituted lower alkyl, optionally substituted aryl, lower alkenyl, lower alkoxy, hydroxy, cyano, nitro, or COR.sup.5 wherein R.sup.5 is as hereinbefore defined; J and G, which may be the same or different, are hydrogen, lower alkyl, optionally substituted aryl, cyano, nitro or trichloromethyl or, together with the geminal hydrogen, the group .dbd.CCl.sub.2 ; or an optical isomer thereof; or a salt thereof; and wherein lower alkyl and lower alkoxy are defined as groups containing from 1 to 6 carbon atoms, lower alkenyl and lower alkanoyl are defined as groups containing from 2 to 6 carbon atoms and lower alkenoyl is defined as a group containing from 3 to 6 carbon atoms; and an inert carrier therefor.

REFERENCES:
patent: 2598234 (1952-05-01), DeGroote et al.
patent: 2730551 (1956-01-01), Beaver et al.
patent: 2783279 (1957-02-01), Chiddix et al.
patent: 2798046 (1957-07-01), Beaver et al.
Vashkov-Chem. Abst., vol. 78, (1973), p. 99468d.

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