Treatment of animals exposed to or subject to exposure to organo

Details Treatment of animals exposed to or subject to exposure to organo Treatment of animals exposed to or subject to exposure to organo

1979-08-21

1981-09-29

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 2, 424 12, A61K 3558, A61K 3938

Patent

active

042923085

ABSTRACT:
A method is provided for treatment of animals exposed to or subject to exposure to organophosphate animal poisonous nerve agents. The animals are injected with an effective amount of modified neurotoxin, preferably intramuscularly or intravenously, either prior to or shortly after exposure to the nerve agents. Particularly when the injection is administered prior to exposure, and where the dosage is of a higher amount, certain compositions achieve 100% survivors of Rhesus monkeys, even in the face of a challenge of 5 LD.sub.50 of the nerve agent.

REFERENCES:
patent: 3888977 (1975-06-01), Sanders
patent: 4162303 (1979-07-01), Sanders
Lee, Snake Venoms, Springer Verlag, N.Y., 1979, pp. 552, 568, 574-576.
Tu, Venoms; Chemistry & Mol. Biol., John Wiley, N.Y., 1977, pp. 178-184.

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