Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-07
1995-01-31
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514453, 514468, 514510, 514691, 514729, 514739, 514766, A01N 4316, A01N 4342, A61K 3147
Patent
active
053859154
ABSTRACT:
A method of regulating phosphorylation of proteins involved in controlling processing or function of key proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques associated with Alzheimer disease comprising introducing an effective amount of a kinase modulator or phosphatase modulator, the modulator capable of increasing or decreasing the rate of proteolytic processing, or modulating the function, of said key proteins.
REFERENCES:
patent: 5242932 (1993-09-01), Gandy et al.
J. L. Biedler et al., "Morphology and Growth, Tumorigenicity, and Cytogenetics of Human Neuroblastoma Cells in Continuous Culture", Cancer Res., 33, pp. 2643-2652.
Buxbaum et al., "Processing of Alzheimer .beta./A4 amyloid precursor protein: Modulation by agents that regulate protein phosyphorylation" Proc. Natl. Acad. Sci. U.S.A., 87, pp. 6003-6006 (1990).
Caporaso et al., "Chloroquine Inhibits Intracellular Degradation But Not Secretion of Alzheimer .beta./A4 Amyloid Precursor Protein", Proc. Natl. Acad. Sci. U.S.A., 87, pp. 2252-2256 (Mar. 15, 1992).
Cole et al., "Evidence for Lysosomal Processing of Amyloid .beta.-Protein Precursor in Cultured Cells", Neurochem. Res., 14, pp. 933-939 (1989).
Crandall et al., "Inverse Diffusion Methods for Data Peak Separation", Anal. Biochem., 167, p. 15 (1987).
Donnelly, R. J. et al., "Interleukin-1 Stimulates the Beta-Amyloid Precursor Protein Promoter", Cell Mol. Neurobiol., 10, pp. 485-495, (1990).
Glenner and Wong, "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein", Biochem Biophys. Res. Commun., 120, pp. 885-890 (1984).
Glenner and Wong, "Alzheimer's Disease and Down's Syndrome sharing of a Unique Cerebrovascular Amyloid Fibril Protein", Biochem Biophys. Res. Commun., 122, pp. 1131-1135 (1984).
Gardella, et al., "Intact Alzheimer Amyloid Precursor Protein (APP) is present in Platelet Membranes and is Encoded by Platelet mRNA", Biochem. Biophys. Res. Commun., 173, pp. 1292-1298 (1990).
Goldgaber et al., "Interleukin 1 regulates syntheis of amyloid .beta.-protein precursor mRNA in human endothelial cells", Proc. Natl. Acad. Sci. USA., 86, pp. 7606-7610 (1989).
Griffin et al., "Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease", Proc. Natl. Acad. Sci. USA., 86, pp. 7611-7615 (1989).
Harlow et al., Antibodies: A Laboratory Manual (Cold Spring Harbor N.Y. 1988).
Huttner et al., "Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium", Proc. Natl. Acad. Sci. U.S.A., 76, pp. 5402-5406 (1979).
Kang et al., "The precursor of Alzheimer's Disease amyloid A4 protein resembles a cell-surface receptor", Nature (London), 325, pp. 733-736 (1987).
E. A. Jaffe, "Culture of Human Endothelial Cell Derived from Umbilical Veins", J. Clin. Invest., 52, pp. 2745-2746.
La Frauci et al., "Characterization of 5'-End Region and the First Two Exons of the .beta.-Protein Precursor Gene", Biochem. Biophys. Res. Commun., 159, pp. 297-304 (1989).
Manning et al., "Identification in rodents and other species of an mRNA homologous to the human .beta.-amyloid precursor", Brain Res., 427, pp. 293-297 (1988).
Masters et al. "Amyloid plaque core protein in Alzheimer disease and Down syndrome", Proc. Natl. Acad. Sci., U.S.A., 82, pp. 4245-4249 (1985).
Pang et al., "Protein tyrosine phosphorylation in synaptic vesicles", Proc. Natl. Acad. Sci. U.S.A., 85, pp. 762-766 (1988).
R. Pinkas-Kramaraki et al., "Growth Factor-Like Effects Mediated by Muscarinic Receptors in PC12M1 Cells", J. Neurochem., 59(6), pp. 2158-2166 (1992).
Podlisny et al., "Gene Dosage of the Amyloid .beta. Precursor Protein in Alzheimer's Disease", Science, 238, pp. 669-671 (1987).
Price et al., "Cellular and Molecular Biology of Alzheimer's Disease", Bio. Assay, 10, pp. 69-71 (1989).
Sisodia et al., "Evidence that .beta.-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing", Science, 248, pp. 492-495 (1980).
R. P. Smith et al., "Platelet Coagulation Factor XI.sub.a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein", Science, 248, pp. 1126-1128 (1990).
St. George-Hyslop et al. "The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21", Science, 235, pp. 885-890 (1987).
Tanzi et al, "The Amyloid .beta. Protein Gene Is Not Duplicated In Brains from Patients with Alzheimer's Disease", Science, 238, pp. 666-669 (1987).
Warren et al., ".beta.-Amyloid Gene Is Not Present in Three Copies of Autopsy-Validated Alzheimer's Disease", Genomic, 1, pp. 307-312 (1987).
Weidemann et al., "Identification, Biogenesis, and Localization of Precursors of Alzheimer's Disease A4 Amyloid Protein", Cell, 57, pp. 115-126 (1989).
Yamada et al., "Structure and Expression of the Alternatively-Spliced Forms of mRNA for the Mouse Homolog of Alzheimer's Disease Amyloid Beta Protein Precursor", Biochem. Biophys. Res. Commun., 158, pp. 906-912 (1987).
Buxbaum Joseph D.
Gandy Samuel E.
Greengard Paul
Nutter Nathan M.
The Rockefeller University
LandOfFree
Treatment of amyloidosis associated with Alzheimer disease using does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of amyloidosis associated with Alzheimer disease using, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of amyloidosis associated with Alzheimer disease using will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1102399